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Your search keyword '"oligoethyleneimine"' showing total 2 results
Start Over Descriptor "oligoethyleneimine" Topic antineoplastic agents
2 results on '"oligoethyleneimine"'

1. Lipoic Acid-Modified Oligoethyleneimine-Mediated miR-34a Delivery to Achieve the Anti-Tumor Efficacy.

Author

Huang Y, Wang L, Chen Y, Han H, and Li Q

Subjects
Apoptosis drug effects, Cell Cycle Checkpoints drug effects, Cell Movement drug effects, Cell Proliferation drug effects, HeLa Cells, Humans, MicroRNAs genetics, Nanoparticles ultrastructure, Polyethyleneimine chemical synthesis, Thioctic Acid chemical synthesis, Wound Healing drug effects, Antineoplastic Agents pharmacology, MicroRNAs metabolism, Polyethyleneimine chemistry, Thioctic Acid chemistry, Transfection
Abstract

MiR-34a, an important tumor suppressor, has been demonstrated to possess great potential in tumor gene therapy. To achieve the upregulation of miR-34a expression level, an oligoethyleneimine (OEI) derivative was constructed and employed as the carrier through the modification with lipoic acid (LA), namely LA-OEI. In contrast to OEI, the derivative LA-OEI exhibited superior transfection efficiency measured by confocal laser scanning microscopy and flow cytometry, owing to rapid cargo release in the disulfide bond-based reduction sensitive pattern. The anti-proliferation and anti-migration effects were tested after the miR-34a transfection to evaluate the anti-tumor response, using human cervical carcinoma cell line HeLa as a model. The delivery of LA-OEI/miR-34a nanoparticles could achieve obvious anti-proliferative effect caused by the induction of cell apoptosis and cell cycle arrest at G1 phase. In addition, it could inhibit the migration of tumor cells via the downregulation of MMP-9 and Notch-1 level. Overall, the LA-OEI-mediated miR-34a delivery was potential to be used as an effective way in the tumor gene therapy.

Published
2021
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2. Lipoic Acid-Modified Oligoethyleneimine-Mediated miR-34a Delivery to Achieve the Anti-Tumor Efficacy

Author

Quanshun Li, Longxiang Wang, Yingxuan Chen, Yu Huang, and Haobo Han

Subjects
Genetic enhancement, Pharmaceutical Science, Organic chemistry, Antineoplastic Agents, Apoptosis, Transfection, Article, Analytical Chemistry, Flow cytometry, HeLa, chemistry.chemical_compound, QD241-441, Downregulation and upregulation, Cell Movement, Drug Discovery, medicine, Humans, Polyethyleneimine, Physical and Theoretical Chemistry, Cell Proliferation, Wound Healing, biology, medicine.diagnostic_test, Thioctic Acid, anti-tumor efficacy, Cell Cycle Checkpoints, biology.organism_classification, lipoic acid, gene therapy, Lipoic acid, MicroRNAs, chemistry, oligoethyleneimine, Chemistry (miscellaneous), Cell culture, Cancer research, Molecular Medicine, Nanoparticles, miR-34a, HeLa Cells
Abstract

MiR-34a, an important tumor suppressor, has been demonstrated to possess great potential in tumor gene therapy. To achieve the upregulation of miR-34a expression level, an oligoethyleneimine (OEI) derivative was constructed and employed as the carrier through the modification with lipoic acid (LA), namely LA-OEI. In contrast to OEI, the derivative LA-OEI exhibited superior transfection efficiency measured by confocal laser scanning microscopy and flow cytometry, owing to rapid cargo release in the disulfide bond-based reduction sensitive pattern. The anti-proliferation and anti-migration effects were tested after the miR-34a transfection to evaluate the anti-tumor response, using human cervical carcinoma cell line HeLa as a model. The delivery of LA-OEI/miR-34a nanoparticles could achieve obvious anti-proliferative effect caused by the induction of cell apoptosis and cell cycle arrest at G1 phase. In addition, it could inhibit the migration of tumor cells via the downregulation of MMP-9 and Notch-1 level. Overall, the LA-OEI-mediated miR-34a delivery was potential to be used as an effective way in the tumor gene therapy.

Published
2021

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