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4 results on '"Blanco Fabiana"'

1. Second generation of α-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical, and biological characterization

Author

López, Gloria V., Blanco, Fabiana, Hernández, Paola, Ferreira, Ana, Piro, Oscar E., Batthyány, Carlos, González, Mercedes, Rubbo, Homero, and Cerecetto, Hugo

Subjects
*ISOPENTENOIDS, *FAT-soluble vitamins, *NITROGEN compounds, *NITRIC oxide
Abstract

Abstract: Synthesis, physicochemical, and biological characterization of a series of α-tocopherol mimetics with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and mammal cytotoxic activities. The lipophilic–hydrophilic balance of all products was also evaluated. A new hybrid furoxan, phenol derivative 17, possesses adequate profile of the studied properties. [Copyright &y& Elsevier]

Published
2007
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2. Design, synthesis, and biological characterization of potential antiatherogenic nitric oxide releasing tocopherol analogs

Author

López, Gloria V., Batthyány, Carlos, Blanco, Fabiana, Botti, Horacio, Trostchansky, Andrés, Migliaro, Eduardo, Radi, Rafael, González, Mercedes, Cerecetto, Hugo, and Rubbo, Homero

Subjects
*VITAMIN E, *NITRIC oxide, *NITROGEN compounds, *ISOPENTENOIDS
Abstract

Abstract: Synthesis and biological characterization of a series of α-tocopherol analogs with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties, and antiplatelet activity. They were also capable of preventing LDL oxidation. [Copyright &y& Elsevier]

Published
2005
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3. Second generation of α-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical, and biological characterization

Author

Paola Hernández, Fabiana Blanco, Hugo Cerecetto, Oscar E. Piro, Mercedes González, Homero Rubbo, Gloria V. López, Ana M. Ferreira, Carlos Batthyány, López Gloria V., Blanco Fabiana, Hernández Paola, Ferreira Ana, Piro Oscar E., Batthyány Carlos, González Mercedes, Rubbo Homero, and Cerecetto Hugo

Subjects
Stereochemistry, Vasodilator Agents, alpha-Tocopherol, Clinical Biochemistry, Pharmaceutical Science, Aorta, Thoracic, Nitric Oxide, Rats, Inbred WKY, Biochemistry, Chemical synthesis, Antioxidants, Nitric oxide, Mice, chemistry.chemical_compound, X-Ray Diffraction, Drug Discovery, Animals, Vitamin E, Nitric Oxide Donors, Phenols, Tocopherol, Molecular Biology, Cell Proliferation, Oxadiazoles, Molecular Structure, Macrophages, Organic Chemistry, Furoxan, Biological activity, Combinatorial chemistry, In vitro, Rats, Vasodilation, chemistry, Molecular Medicine, NO donor, Antioxidant, LDL oxidation
Abstract

Synthesis, physicochemical, and biological characterization of a series of alpha-tocopherol mimetics with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and mammal cytotoxic activities. The lipophilic-hydrophilic balance of all products was also evaluated. A new hybrid furoxan, phenol derivative 17, possesses adequate profile of the studied properties.

Published
2007

4. Design, synthesis, and biological characterization of potential antiatherogenic nitric oxide releasing tocopherol analogs

Author

Eduardo R. Migliaro, Andrés Trostchansky, Hugo Cerecetto, Gloria V. López, Mercedes González, Carlos Batthyány, Homero Rubbo, Horacio Botti, Fabiana Blanco, Rafael Radi, López Gloria V., Batthyány Carlos, Blanco Fabiana, Botti Horacio, Trostchansky Andrés, Migliaro Eduardo, Radi Rafael, González Mercedes, and Cerecetto Hugo

Subjects
Antioxidant, Magnetic Resonance Spectroscopy, Spectrophotometry, Infrared, medicine.medical_treatment, Vasodilator Agents, Clinical Biochemistry, Pharmaceutical Science, Tocopherols, In Vitro Techniques, Nitric Oxide, Biochemistry, Chemical synthesis, Antioxidants, Nitric oxide, chemistry.chemical_compound, Drug Discovery, medicine, Organic chemistry, Animals, Humans, Nitric Oxide Donors, Tocopherol, Rats, Wistar, Molecular Biology, Bicyclic molecule, Chemistry, Organic Chemistry, Furoxan, Atherosclerosis, In vitro, Rats, Design synthesis, Molecular Medicine
Abstract

Postprint Synthesis and biological characterization of a series of tocopherol analogs with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and antiplatelet activity. They were also capable to prevent LDL oxidation.

Published
2005

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