1. Phytochemical and medicinal profiling of Russula vinosa Lindbl (RVL) using multiomics techniques.
- Author
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Chen, Hongwei, Zhou, Hailin, She, Zhiyong, Lu, Huihua, Wen, Mingsen, Wang, Xuancheng, Wei, Zhijuan, Yang, Shanyi, Guan, Xuan, Tong, Ying, Qin, Qixuan, Zhu, Pingchuan, Nong, Yanying, and Zhang, Qisong
- Subjects
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MULTIOMICS , *BIOACTIVE compounds , *EDIBLE fungi , *ANTIOXIDANT analysis , *LIPIDOMICS , *ORGANIC acids - Abstract
Russula vinosa Lindbl (RVL) is a multifunctional edible fungus that has recently gained widespread attention due to its numerous nutritious, delicious, and medicinal properties. However, little attention has been directed toward analyzing comprehensive phytochemical profiling and bioactivity in RVL. This study aimed to evaluate the phytochemical and medicinal profiling of RVL systematically. Herein, we characterized global RVL phytochemical profiling using the LC/GC-MS-based multiomics strategy through initial methodological optimization. A total of 633 metabolites were identified using untargeted multiomics, with fatty acids, amino acids, polyphenols, terpenoids, organic acids, sugars, and phospholipids as the primary metabolites. Polyphenols served as the main active components by quantitative analysis and antioxidant evaluation, impling that they may be related to antitumor effects. Moreover, based on phytochemical profiling, the potential gene targets and mechanisms of anticancer properties of RVL were explored through network pharmacology. The significance of this study lies in expanding our understanding of the phytochemical and bioactive components of RVL and providing references for its further utilization and exploitation. Therefore, RVL could be an excellent raw material for the food, nutraceutical, and pharmaceutical industries due to its richness in nutrients and bioactive ingredients. • Initial methodological optimization to establish reliable analytical method. • Combining metabolomics and lipidomics to reveal global phytochemicals of RVL. • Polyphenols are the main bioactives of RVL with good antioxidant activity. • Using network pharmacology to explore targets and mechanism of RVL' antitumor. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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