1. Biological activities of Fructus arctii fermented with the basidiomycete Grifola frondosa
- Author
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Min-Hyeon Song, Jin-Hwa Kim, Geun-Su Lee, Soo Young Choe, Jun-Tae Bae, and Hyeong-Bae Pyo
- Subjects
Antioxidant ,Ultraviolet Rays ,medicine.medical_treatment ,Lipoxygenase ,Cosmetics ,Biology ,Matrix Metalloproteinase Inhibitors ,Antioxidants ,chemistry.chemical_compound ,Drug Discovery ,medicine ,Caffeic acid ,Medicinal fungi ,Humans ,Lipoxygenase Inhibitors ,RNA, Messenger ,Arctigenin ,Grifola frondosa ,Cells, Cultured ,chemistry.chemical_classification ,Mycelium ,Plant Extracts ,beta-Glucosidase ,Organic Chemistry ,Arctiin ,Glycoside ,Biological activity ,Dermis ,Fibroblasts ,Arctium ,Biochemistry ,chemistry ,Fermentation ,Molecular Medicine ,Matrix Metalloproteinase 1 ,Grifola - Abstract
Fructus arctii extract containing phenolic glycosides was cultured with Grifola frondosa mycelia to produce β-glucosidase and its biological activities were studied. This β-glucosidase converted the glycosides (arctiin and caffeic acid derivatives) into aglycones (arctigenin and caffeic acid). Fermented Fructus arctii extract (G-FAE) with G. frondosa had antioxidant and 5-lipoxygenase inhibitory activities. The photoprotective potential of G-FAE was tested in human dermal fibroblasts (HDF) exposed to ultra-violet A (UVA). It was revealed that G-FAE had an inhibitory effect on human interstitial collagenase (matrix metalloproteinase, MMP-1) expression in UVA-irradiated HDF. The treatment of UVA-irradiated HDF with G-FAE resulted in a dose-dependent decrease in the expression level of MMP-1 mRNA. G-FAE also showed notable stimulation of collagen biosynthetic activity for fibroblasts. These diverse functionalities suggest that G-FAE could be a promising cosmetic ingredient.
- Published
- 2010