1. A functional polysaccharide from Eriobotrya japonica relieves myocardial ischemia injury via anti-oxidative and anti-inflammatory effects.
- Author
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Huang X, Hou R, Pan W, Wu D, Zhao W, and Li Q
- Subjects
- Animals, Cell Line, Mice, Myocardial Ischemia metabolism, Plant Leaves chemistry, Rats, Anti-Inflammatory Agents chemistry, Anti-Inflammatory Agents pharmacology, Antioxidants chemistry, Antioxidants pharmacology, Eriobotrya, Myocardial Reperfusion Injury metabolism, Polysaccharides chemistry, Polysaccharides pharmacology
- Abstract
We herein report a food-derived polysaccharide (EJP) with the effect of relieving myocardial ischemia reperfusion injury (MIRI). This novel polysaccharide was isolated from the leaf of Eriobotrya japonica , and we first found its myocardium protective effects in vitro . Then, we firstly characterized EJP with a series of analytical technologies and further tested its effect on myocardial ischemia reperfusion injury (MIRI) with the illustration of the potential mechanisms in vivo . Interestingly, in the murine model of MIRI, administration of EJP effectively improved post-I/R heart contraction and limited the infarct size. Moreover, EJP significantly attenuated IR-induced oxidative damage and inflammatory reaction, as evidenced by decreasing MDA, IL-6, and TNF-α contents and increasing SOD activity and GSH-Px expression. In addition, we proved that EJP not only had no nephrotoxicity but also demonstrated a protective effect on the kidneys through HE staining and biochemical analysis. In sum, EJP, with a significant protective effect against myocardial I/R injury by showing anti-inflammatory and anti-oxidative activities, may become a meaningful drug candidate for the treatment of myocardial I/R injury.
- Published
- 2022
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