1. Tissue factor in the antiphospholipid syndrome.
- Author
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Kinev AV and Roubey RA
- Subjects
- Antigen-Antibody Reactions physiology, Antiphospholipid Syndrome metabolism, Antiphospholipid Syndrome therapy, Gene Expression Regulation physiology, Humans, Signal Transduction physiology, Antibodies, Antiphospholipid physiology, Antiphospholipid Syndrome etiology, Thromboplastin physiology
- Abstract
Antiphospholipid (aPL) antibodies are clinically important acquired risk factors for thrombosis and pregnancy loss and are thought to have a direct prothrombotic effect in vivo. Data suggest that a major mechanism by which aPL antibodies contribute to thrombophilia is the upregulation of tissue factor (TF) (CD142) on blood cells and vascular endothelium. TF is the physiological trigger of normal blood coagulation and thrombosis in many hypercoagulable conditions. This article reviews the physiology of TF, the molecular regulation of TF expression and the effects of aPL antibodies on intravascular TF regulation and expression. Inhibition of TF and the pathways by which aPL antibodies induce TF expression are potentially attractive therapeutic targets in the antiphospholipid syndrome.
- Published
- 2008
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