1. Eupulcherol A, a triterpenoid with a new carbon skeleton from Euphorbia pulcherrima, and its anti-Alzheimer's disease bioactivity.
- Author
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Yu CX, Wang RY, Qi FM, Su PJ, Yu YF, Li B, Zhao Y, Zhi DJ, Zhang ZX, and Fei DQ
- Subjects
- Alzheimer Disease parasitology, Animals, Antiprotozoal Agents chemistry, Antiprotozoal Agents isolation & purification, Dose-Response Relationship, Drug, Molecular Structure, Parasitic Sensitivity Tests, Structure-Activity Relationship, Triterpenes chemistry, Triterpenes isolation & purification, Alzheimer Disease drug therapy, Antiprotozoal Agents pharmacology, Caenorhabditis elegans drug effects, Euphorbia chemistry, Triterpenes pharmacology
- Abstract
Eupulcherol A (1), a novel triterpenoid with an unprecedented carbon skeleton, was isolated from Euphorbia pulcherrima. Its structure was determined by comprehensive analysis of spectroscopic data, including HRESIMS and 1D and 2D NMR, and the absolute configuration was defined by single crystal X-ray diffraction analysis. Biological studies showed that compound 1 possessed anti-Alzheimer's disease (AD) bioactivity, which could delay paralysis of transgenic AD Caenorhabditis elegans. A plausible biogenetic pathway for eupulcherol A (1) was also proposed.
- Published
- 2019
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