1. A thirty day course of sodium stibogluconate for treatment of Kala-azar in Nepal.
- Author
-
Karki P, Koirala S, Parija SC, Hansdak SG, and Das ML
- Subjects
- Adolescent, Adult, Antimony Sodium Gluconate administration & dosage, Antiprotozoal Agents administration & dosage, Child, Female, Humans, Male, Middle Aged, Nepal, Antimony Sodium Gluconate therapeutic use, Antiprotozoal Agents therapeutic use, Leishmaniasis, Visceral drug therapy
- Abstract
Twenty-seven cases of Kala-azar were treated with sodium stibogluconate at a dose of 20 mg/kg/day for 20 days (group A) and an equal number of cases were treated with the same dose but for a longer duration of 30 days (group B). Clinical and laboratory evaluation of these cases were carried out before and after therapy, during a follow up of cases every month, upto 6 months. Renal and liver function tests and electrocardiography were carried out of monitor any toxic effect of the drug during therapy. The cure rates of patients were 77.78% and 92.59% in group A and B cases respectively. Six and two patients in group A and B respectively were unresponsive to the treatment and showed relapse. Results of the study show that treatment of cases of Kala-azar with sodium stibogluconate in a dosage of 20 mg/kg/day for a longer period of 30 days is effective with a higher cure rate and minimum side effects, for treatment of cases of Kala-azar in this eastern part of Nepal, endemic for the disease.
- Published
- 1998