1. Antiretroviral therapy during tuberculosis treatment and marked reduction in death rate of HIV-infected patients, Thailand.
- Author
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Akksilp, Somsak, Karnkawinpong, Opart, Wattanaamornkiat, Wanpen, Viriyakitja, Daranee, Monkongdee, Patama, Sitti, Walya, Rienthong, Dhanida, Siraprapasiri, Taweesap, Wells, Charles D., Tappero, Jordan W., and Varma, Jay K.
- Subjects
ANTIRETROVIRAL agents ,TUBERCULOSIS treatment ,HIV-positive persons ,CO-trimoxazole ,HIV infection complications ,TUBERCULOSIS mortality ,DRUG therapy for tuberculosis ,HIV infections ,ANTI-HIV agents ,RESEARCH ,CONFIDENCE intervals ,MULTIVARIATE analysis ,RESEARCH methodology ,MEDICAL cooperation ,EVALUATION research ,TREATMENT effectiveness ,COMPARATIVE studies ,ANTITUBERCULAR agents ,ODDS ratio ,LONGITUDINAL method - Abstract
Antiretroviral therapy (ART) is lifesaving in patients with advanced HIV infection, but the magnitude of benefit in HIV-infected patients receiving tuberculosis (TB) treatment remains uncertain, and population-based data from developing countries are limited. We prospectively collected data about HIV-infected TB patients from February 2003 through January 2004 in Ubon-ratchathani, Thailand. During 12 months, HIV was diagnosed in 329 (14%) of 2,342 patients registered for TB treatment. Of patients with known outcomes, death during TB treatment occurred in 5 (7%) of 71 who received ART and 94 (43%) of 219 who did not. Using multivariate analysis, we found a large reduction in the odds of death for patients receiving ART before or during TB treatment (odds ratio, 0.2; 95% confidence interval, 0.1-0.5), adjusting for CD4 count, smear status, co-trimoxazole use, and treatment facility. ART is associated with a substantial reduction in deaths during TB treatment for HIV-infected TB patients in Thailand. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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