1. Cytotoxic triterpenes from the acid hydrolyzate of Gynostemma pentaphyllum saponins.
- Author
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Shi, Lin, Tan, De-Hong, Yan, Ting-Cai, Jiang, Dong-Hua, and Hou, Ming-Xiao
- Subjects
ANTINEOPLASTIC agents ,BIOLOGICAL assay ,CELL culture ,CELL lines ,CHROMATOGRAPHIC analysis ,GLYCOSIDES ,MASS spectrometry ,MOLECULAR structure ,NUCLEAR magnetic resonance spectroscopy ,PHARMACEUTICAL chemistry ,RESEARCH funding ,TERPENES ,TOXICITY testing ,TUMORS ,IN vitro studies - Abstract
One new dammarane-type triterpene, gypsapogenin A (1), was isolated from the acid hydrolyzate of total saponins fromGynostemma pentaphyllum(Thunb.) Makino, together with two known compounds, (20S,24S)-3β,20,21β,23β,25-pentahydroxy-21,24-cyclodammarane (2) and (23S)-3β-hydroxydammar-20,24-dien-21-oic acid 21,23-lactone (3). Its structural elucidations were accomplished mainly on the basis of the interpretation of spectroscopic data, such as IR, HR-TOF-MS, and NMR. The cytotoxic activities were evaluated against HepG2 and A549 human cancer cell lines. [ABSTRACT FROM PUBLISHER]
- Published
- 2018
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