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Your search keyword '"Kornet, Maryna N."' showing total 1 results
Start Over Author "Kornet, Maryna N." Topic antiviral agents
1 results on '"Kornet, Maryna N."'

1. Study of the Chemoselectivity of Multicomponent Heterocyclizations Involving 3-Amino-1,2,4-triazole and Pyruvic Acids as Key Reagents, and Biological Activity of the Reaction Products.

Author

Murlykina, Maryna V., Sakhno, Yana I., Desenko, Sergey M., Shishkina, Svetlana V., Shishkin, Oleg V., Sysoiev, Dmytro O., Kornet, Maryna N., Schols, Dominique, Goeman, Jan L., Van der Eycken, Johan, Van der Eycken, Erik V., and Chebanov, Valentin A.

Subjects
CHEMOSELECTIVITY, MICROWAVE chemistry, RING formation (Chemistry), ANTIVIRAL agents, ALDEHYDES
Abstract

Three-component reactions involving 3-amino-1,2,4-triazole, aldehydes, including salicylic aldehydes, and pyruvic acids were studied in detail. The reaction pathway and products of the heterocyclizations could be changed by variation of the reaction parameters. The broad antimicrobial activity of the products was also studied. Compound 9d showed specific anti-influenza virus (A/H1N1) activity, with an IC50 of 0.57 μ M and a CC50 of >100 μ M. [ABSTRACT FROM AUTHOR]

Published
2015
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