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Despite the formal declaration of the end of the global health emergency related to COVID-19, the disease continues to pose significant challenges worldwide. This study addresses the gap in existing literature regarding the impact of COVID-19 anxiety on university students during the peak of the pandemic. Specifically, it examined how COVID-19 anxiety influenced the meaning in life, life orientation, and academic motivation; variables that are known predictors of student success and their overall well-being. Conducted as a non-experimental quantitative cross-sectional study, data were collected from 557 participants selected through purposive sampling. The research used the Coronavirus Pandemic Anxiety Scale, Academic Motivation Scale, Revised Life Orientation Test, and the Meaning in Life Questionnaire to gather relevant data. Findings reveal that COVID-19 anxiety has a negative influence on academic motivation, presence of meaning, and life orientation. The results also indicate a positive relationship between COVID-19 anxiety and the search for meaning in life. These findings not only enhance the understanding of the pandemic's adverse impacts on university students but also provide a basis for future interventions and strategies by educational stakeholders and policymakers aimed at mitigating these effects. [ABSTRACT FROM AUTHOR]