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Introduction: Social anxiety is characterized by marked anxiety, cognitive and emotional dysfunction in social situations and can lead to social avoidance behavior. The purpose of this study was to investigate the mediating role of self-criticism in the relationship between the fear of negative evaluation and self-compassion with social anxiety in Yazd medical students. Methods: A correlational research study was conducted using structural equation modeling. The statistical population of the research consisted of all students of medicine, pharmacy and dentistry of Shahid Sadougi University of Medical Sciences in Yazd in the academic year of 2021-2022. The sample size of 250 people was determined; sampling was done by voluntary sampling method. Research instruments included social anxiety scale (Jarabek, 1996), fear of negative evaluation (Leary, 1983), short form of self-compassion (Rees et al., 2011) and self-criticism (Thompson and Zaroff, 2004), which were published online. Finally, the data of 227 students were analyzed by Pearson correlation and structural equation model using SPSS16 and Amos24 software. Results: The results showed that the direct effect of fear of negative evaluation and self-criticism on social anxiety was significant (P

Introduction: This study aimed to evaluate the effectiveness of combination therapy with sertraline and compassion-enriched act on depression, stress, and anxiety in opioid abuse patients treated with methadone compared to intervention based on compass-enriched acceptance and commitment treatment alone.Methods: This study was a clinical trial with a pre-test and post-test design. Forty people were selected by voluntary sampling method; after matching, they were divided into two groups with 15 participants. The first group received compassion-enriched acceptance and commitment treatment and the second group received combination therapy with compassion-enriched acceptance and commitment treatment and sertraline for 28 days. Patients were evaluated based on the Anxiety-Stress-Depression Questionnaire (DASS-21). Data were analyzed using SPSS version 16, multivariate analysis of covariance test at the level of 0.05. Results: The results showed that both interventional methods effectively treat depression, stress, and anxiety (p