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This article discusses the potential of long noncoding RNAs (lncRNAs) in understanding thoracic aortic diseases. The researchers identified two lncRNAs, TMEM72-AS1 and LINC00632, that are expressed in vascular smooth muscle cells and differ between dilated and non-dilated areas of the aorta. The expression of these lncRNAs was significantly higher in dilated areas, particularly in tissues from patients with bicuspid aortic valve (BAV) and aortic regurgitation (AI). The findings suggest that these lncRNAs could be potential targets for diagnostic and therapeutic interventions in thoracic aortic diseases. [Extracted from the article]