Search

The objective of this prospective study was to assess matrix metalloproteinase 9 (MMP-9) activity in patients undergoing open surgery or endovascular repair of abdominal aortic aneurysms (AAAs), comparing changes in plasma levels in the two groups. We studied 12 patients after conventional open surgery and 9 patients after endovascular aneurysm repair. MMP-9 was assayed in plasma at baseline and 1 week and 1 month thereafter. Preoperative MMP-9 levels were similar in the two groups (41.7 +/- 19.1 vs 44.4 +/- 24.6 ng/mL; p = not significant). Assessment 1 week later showed that MMP levels in both repair groups had increased. In the open surgery group, they increased significantly (59.7 +/- 16.8 ng/mL; p < .05) but not in the endovascular group (49.3 +/- 32.4 ng/mL). One month later, MMP-9 levels decreased in both groups but not significantly (to 32.6 +/- 24.6 ng/mL for open surgery repair and to 34.7 +/- 23.5 ng/mL for endovascular repair). At 1 month after repair, MMP-9 levels decreased significantly only in smokers, whereas in nonsmokers, they did not (from 46.9 +/- 22.1 to 31.7 +/- 21.5 ng/mL in smokers [p < .05] vs from 34.7 +/- 17.4 to 37.1 +/- 28.9 ng/mL in nonsmokers). This study confirms that enzyme secretion changes during the postoperative course. The differing patterns of MMP-9 expression prevent us from reaching definitive conclusions about the use of MMP-9 as a marker during early postprocedural follow-up. An important matter to clarify is the role of MMP-9 in long-term follow-up, especially after endovascular AAA repairs. [ABSTRACT FROM AUTHOR]

The rupture of an abdominal aortic aneurysms (AAAs) is associated with a mortality rate exceeding 50%. To reduce this figure it is necessary to increase the frequency of early diagnosis and elective surgery. Screening the general population for occult AAAs has proven cost ineffective. Only by identifying high-risk subgroups will screening programs be improved. The aim of this report was to investigate by ultrasonography the prevalence of previously unknown aortic dilatations among first-degree relatives (parents, siblings, and children) of patients operated on for AAAs. Ninety-one (52.6%) of the 173 living first degree-relatives of 51 patients who underwent AAA resection were submitted to an aortoiliac ultrasonographic examination to establish aortic diameter and morphology. There was at least 1 first-degree relative with an AAA (multiplex family) in 10 families (19.6%) before ultrasound screening. With ultrasound a previously unknown infrarenal aortic dilatation was detected in 14 subjects (9 men/5 women; 10 siblings and 4 children) of 12 different families. Specifically, these aortic dilatations consisted of 10 AAAs (diameters ranged from 2.6 to 4.3 cm) and 4 aortic blebs. These occult aortic dilatations were located in 50% of cases in the lower third of the infrarenal abdominal aorta. The cumulative incidence of multiplex families was 35.3%. This study suggests a familial tendency to have an important etiologic role in the formation of AAAs. Family screening of, above all, male siblings older than forty-five years will help identify occult AAAs and reduce the mortality rates associated with their rupture. [ABSTRACT FROM AUTHOR]