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Your search keyword '"Viviana Donoso"' showing total 3 results
Start Over Author "Viviana Donoso" Topic apiaceae
3 results on '"Viviana Donoso"'

1. Antimicrobial Diterpenes from Azorella Species Against Gram-Positive Bacteria

Author

Viviana, Donoso, Mitchell, Bacho, Solange, Núiñez, Juana, Rovirosa, Aurelio, San-Martin, and Sergio, Leiva

Subjects
Molecular Structure, Plant Extracts, Microbial Sensitivity Tests, Diterpenes, Gram-Positive Bacteria, Anti-Bacterial Agents, Apiaceae
Abstract

The present study was aimed at evaluating the antibacterial activity of mulinane and azorellane diterpenes isolated from the Andean plants Azorella compacta and A. trifoliolata and semisynthetic derivatives against reference and multidrug-resistant strains. The results revealed that the semisynthetic compound 7-acetoxy-mulin-9,12-diene (5) exhibited antibacterial activity against reference and multidrug-resistant strains of Staphylococcus aureus and moderate antimycobacterial activity against Mycobacterium smegmatis ATCC 14468.

Published
2016

2. Antimicrobial Diterpenes from Azorella Species against Gram-Positive Bacteria

Author

Solange Núiñez, Sergio Leiva, Mitchell Bacho, Aurelio San-Martín, Viviana Donoso, and Juana Rovirosa

Subjects
Pharmacology, Apiaceae, biology, medicine.drug_class, Chemistry, Gram-positive bacteria, Mycobacterium smegmatis, Azorella, Plant Science, General Medicine, biology.organism_classification, Antimycobacterial, Antimicrobial, medicine.disease_cause, Microbiology, Complementary and alternative medicine, Staphylococcus aureus, Drug Discovery, medicine, Antibacterial activity
Abstract

The present study was aimed at evaluating the antibacterial activity of mulinane and azorellane diterpenes isolated from the Andean plants Azorella compacta and A. trifoliolata and semisynthetic derivatives against reference and multidrug-resistant strains. The results revealed that the semisynthetic compound 7-acetoxy-mulin-9,12-diene (5) exhibited antibacterial activity against reference and multidrug-resistant strains of Staphylococcus aureus and moderate antimycobacterial activity against Mycobacterium smegmatis ATCC 14468.

Published
2015
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3. Molecular docking studies of the antitumoral activity and characterization of new chalcone

Author

Omar Malagon Aviles, Aurelio San-Martín, Mitchell Bacho, Natalia Bailon-Moscoso, Juana Rovirosa, Margarita Gutiérrez, Solange Nunez, Sandra Cuenca Camacho, Sergio Leiva, Maria-Elena Cazar, and Viviana Donoso

Subjects
Klebsiella granulomatis, Chalcone, Free Radicals, Stereochemistry, DPPH, Microbial Sensitivity Tests, medicine.disease_cause, Structure-Activity Relationship, chemistry.chemical_compound, Chalcones, Drug Discovery, medicine, Humans, Escherichia coli, Bacteria, Molecular Structure, biology, Mycobacterium smegmatis, General Medicine, biology.organism_classification, Antineoplastic Agents, Phytogenic, Anti-Bacterial Agents, Biochemistry, chemistry, Docking (molecular), Staphylococcus aureus, Morganella morganii, Apiaceae
Abstract

Phytochemical investigation of Azorella madreporica led to the isolation of four known compounds and an unknown chalcone. The structure of the new compound was identified by spectroscopy, including two-dimensional NMR techniques and comparison with published spectral data. The antioxidant activity of chalcone (compound 1) was measured using the 1,2-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging assay, and the bioactivity was evaluated against five bacteria (Mycobacterium smegmatis ATCC 14468, clinical isolates of Staphylococcus aureus, Klebsiella granulomatis, Morganella morganii and Escherichia coli) and four cancer cell lines. Docking studies with the tested cancer related proteins revealed nearby values of energy between doxorubicin and compound 1. Besides, protein-ligand interactions correlate with these energy values.

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