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1. Progesterone treatment improves cognitive outcome following experimental traumatic brain injury in rats.

Author

Si, Daowen, Wang, Haitao, Wang, Qian, Zhang, Chengyun, Sun, Jingyu, Wang, Zhigang, Zhang, Zuofeng, and Zhang, Yuxin

Subjects
*PROGESTERONE, *BRAIN injury treatment, *COGNITION disorders treatment, *LABORATORY rats, *CASPASES, *APOPTOSIS, *HEALTH outcome assessment, *ENCEPHALITIS, *THERAPEUTICS
Abstract

Highlights: [•] High levels of COX-2 and caspase-3 and cognitive deficits were detected in injury. [•] Progesterone reduces the expressions of COX-2 and caspase-3 after brain injury. [•] Progesterone improves cognitive functional outcomes after brain injury. [•] The progesterone mechanism is associated with inhibiting inflammation and apoptosis. [ABSTRACT FROM AUTHOR]

Published
2013
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