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Your search keyword '"Yin, Yi"' showing total 4 results
Start Over Author "Yin, Yi" Topic apoptosis Topic cell proliferation
4 results on '"Yin, Yi"'

1. Therapeutic Opportunities in Colorectal Cancer: Focus on Melatonin Antioncogenic Action.

Author

Wu, Hucong, Liu, Jiaqi, Yin, Yi, Zhang, Dong, Xia, Pengpeng, and Zhu, Guoqiang

Subjects
METASTASIS, TUMOR prevention, COLON tumor prevention, PREVENTION of disease progression, AUTOPHAGY, CELL proliferation, APOPTOSIS, CELL lines, CIRCADIAN rhythms, COMBINED modality therapy, COLON tumors, DISEASES, IMMUNE system, MELATONIN, RECTUM tumors, DISEASE incidence, PATHOLOGIC neovascularization, TUMOR risk factors, PREVENTION, CANCER risk factors, THERAPEUTICS
Abstract

Colorectal cancer (CRC) influences individual health worldwide with high morbidity and mortality. Melatonin, which shows multiple physiological functions (e.g., circadian rhythm, immune modulation, and antioncogenic action), can be present in almost all organisms and found in various tissues including gastrointestinal tract. Notably, melatonin disruption is closely associated with the elevation of CRC incidence, indicating that melatonin is effective in suppressing CRC development and progression. Mechanistically, melatonin favors in activating apoptosis and colon cancer immunity, while reducing proliferation, autophagy, metastasis, and angiogenesis, thereby exerting its anticarcinogenic effects. This review highlights that melatonin can be an adjuvant therapy and be beneficial in treating patients suffering from CRC. [ABSTRACT FROM AUTHOR]

Published
2019
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2. Isokotomolide A, a new butanolide extracted from the leaves of Cinnamomum kotoense, arrests cell cycle progression and induces apoptosis through the induction of p53/p21 and the initiation of mitochondrial system in human non-small cell lung cancer A549 cells

Author

Yin-Yi Chen, Po-Lin Kuo, Ya-Ling Hsu, Jen-Yu Hung, Chung-Yi Chen, and Ming-Shyan Huang

Subjects
Pharmacology, A549 cell, Cyclin-Dependent Kinase Inhibitor p21, Programmed cell death, Cyclin E, Lung Neoplasms, Cell growth, Cell Cycle, Apoptosis, Biology, Cell cycle, Antineoplastic Agents, Phytogenic, Cell biology, Mitochondria, Cyclin D1, 4-Butyrolactone, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Cancer research, biology.protein, Humans, Cyclin-dependent kinase 6, Tumor Suppressor Protein p53, Cell Proliferation
Abstract

This study is the first to investigate isokotomolide A (IKA), a butanolide compound isolated from the leaves of Cinnamomum kotoense Kanehira & Sasaki (Lauraceaee), which exhibits an anti-proliferative activity in human non-small cell lung cancer A549 cells. The results show that IKA inhibits the proliferation of A549 by blocking cell cycle progression in the G0/G1 phase and inducing apoptosis. Blockade of cell cycle was associated with increased p21/WAF1 levels and reduced amounts of cyclin D1, cyclin E, Cdk2, Cdk4, and Cdk6 in a p53-mediated manner. IKA treatment also increased p53 phosphorylation (Ser15) and decreased the interaction of p53-MDM2. IKA treatment triggered the mitochondrial apoptotic pathway, indicated by changing Bax/Bcl-2 ratios, cytochrome c release and caspase-9 activation. In addition, pre-treatment of cells with caspase-9 inhibitor inhibited IKA-induced apoptosis, indicating that caspase-9 activation was involved in A549 cells' apoptosis induced by IKA. Our study reports here for the first time that the induction of p53/p21 and the initiation of the mitochondrial apoptotic system may participate in the anti-proliferative activity of IKA in human non-small cell lung cancer cells.

Published
2007

3. Rugosin E, an ellagitannin, inhibits MDA-MB-231 human breast cancer cell proliferation and induces apoptosis by inhibiting nuclear factor-kappaB signaling pathway

Author

Yin-Yi Chen, Chun-Ching Lin, Ta-Chen Lin, Po-Lin Kuo, Wen-Sheng Tzeng, and Ya-Ling Hsu

Subjects
Cancer Research, Cyclin E, Blotting, Western, Apoptosis, Breast Neoplasms, Cell Cycle Proteins, Electrophoretic Mobility Shift Assay, Biology, Cyclin D1, Cyclin D2, Cell Line, Tumor, Humans, Cell Proliferation, Dose-Response Relationship, Drug, Cell growth, Reverse Transcriptase Polymerase Chain Reaction, Cell Cycle, NF-kappa B, Cell cycle, Hydrolyzable Tannins, XIAP, Cell biology, Oncology, Cancer research, biology.protein, Female, Cyclin-dependent kinase 6, Signal Transduction
Abstract

In this study, we first report the chemopreventive effect of rugosin E in human breast cancer cell line, MDA-MB-231. Treatment with rugosin E decreased the cell proliferation of MDA-MB-231 cells in a dose-dependent manner. Rugosin E treatment arrested MDA-MB-231 cells at G0/G1 phase. This effect was strongly associated with concomitant decrease in the level of cyclin D1, cyclin D2, cyclin E, cdk2, cdk4, and cdk6, and increase of p21/WAF1. In addition, rugosin E also induced apoptotic cell death. Rugosin E increased in the expression of Bax, Bak, and Bcl-Xs, but decreased the levels of Bcl-2 and Bcl-X(L), and subsequently triggered mitochondria apoptotic pathway (release of cytochrome c, activation of caspase-9, and caspase-3). In addition, pre-treatment of cells with caspase-9 inhibitor blocked rugosin E-induced cell proliferation and apoptosis, indicating caspase-9 activation was involved in rugosin E-mediated MDA-MB-231 cells apoptosis. Rugosin E inhibited the constitutively activated and inducible NF-kappaB in both its DNA-binding activity and transcriptional activity. Furthermore, rugosin E also inhibited the TNF-alpha-activated NF-kappaB-dependent reporter gene expression of cyclin D1, c-Myc, XIAP, Bcl-2, and Bcl-X(L) were all downregulated by rugosin E. Our results indicated that rugosin E inhibits the activation of NF-kappaB, and this may provide a molecular basis for drug development in the prevention and treatment of cancer by rugosin E.

Published
2006

4. Ligustilide prevents the apoptosis effects of tumour necrosis factor-alpha during C2C12 cell differentiation.

Author

Shi, Ying, Wang, Dongtao, Lu, Lu, Yin, Yi, Wang, Ming, Li, Chengjie, Diao, Jianxin, Wang, Yanjing, and Wei, Lianbo

Subjects
*TUMOR necrosis factors, *CELL differentiation, *CELL lines, *DONG quai, *BIOACTIVE compounds, *NERVE tissue, *CELL proliferation, APOPTOSIS prevention
Abstract

Abstract: Ligustilide, the major component of Angelica sinensis, is also thought to be the most potent bioactive constituent of this plant. Ligustilide has been reported to markedly protect neural tissue against apoptosis. However, little is known regarding ligustilide's anti-apoptosis effect in muscle tissue. The aim of the study was to investigate the anti-apoptosis effects of ligustilide on TNF-α-induced C2C12 cells during differentiation. It was revealed that ligustilide at various concentrations significantly prevented the apoptosis of C2C12 cells incubated in TNF-α as assessed by apoptosis index and DNA fragmentation. Moreover, ligustilide-treated groups exhibited a significant increase in the bcl-2/bax ratio, pro-caspase 3 and pro-caspase 8 compared with the TNF-α-control group in a dose-dependent manner. Meanwhile, ligustilide-treated groups presented a significantly increased level of phosphorylated Akt and suppressed expression of the myogenin protein. Therefore, the findings derived suggested that ligustilide protected C2C12 cells from TNF-α-induced apoptosis during differentiation by reducing apoptosis and inducing cell proliferation. [Copyright &y& Elsevier]

Published
2014
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