1. Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation.
- Author
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O'Riordan MX, Bauler LD, Scott FL, and Duckett CS
- Subjects
- Amino Acid Motifs, Amino Acid Sequence, Animals, Apoptosis genetics, Caspases metabolism, Inhibitor of Apoptosis Proteins chemistry, Inhibitor of Apoptosis Proteins genetics, Models, Biological, Molecular Sequence Data, Protein Binding genetics, Protein Structure, Tertiary genetics, Sequence Homology, Amino Acid, Apoptosis physiology, Evolution, Molecular, Inhibitor of Apoptosis Proteins metabolism
- Abstract
The past decade and a half has witnessed the discovery of a large, evolutionarily conserved family of cellular genes bearing homology to the prototype baculovirus Inhibitor of Apoptosis (IAP). The logical decision in the field to also refer to these cellular proteins as IAPs fails to do justice to this versatile group of factors that play a wide range of roles in eukaryotic development and homeostasis which include, but are not limited to, the regulation of programmed cell death. Here we describe the shared functional characteristics of several well-characterized IAPs whose defining motifs place them more in the category of multifunctional modular protein interaction domains.
- Published
- 2008
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