1. Role of apoptosis and Fas/FasL system in the oogenesis of the spotted ray Torpedo marmorata.
- Author
-
Loredana R, Barbara D, Annamaria L, Stefania T, Maria MC, Silvana F, Piero A, and Marina P
- Subjects
- Animals, Fas Ligand Protein, Female, In Situ Nick-End Labeling, Oocytes metabolism, Ovarian Follicle metabolism, Torpedo metabolism, Apoptosis physiology, Membrane Glycoproteins metabolism, Oogenesis physiology, fas Receptor metabolism
- Abstract
In the present paper we investigated the role played by apoptosis during oogenesis in the cartilaginous fish Torpedo marmorata. TEM, TUNEL and immunohistochemical techniques were employed to specifically reveal morphological and biochemical hallmarks of apoptosis in specimens from birth to sexual maturity. Data obtained demonstrate that apoptosis occurs in prefollicular oocyte selection, in maintaining the homeostasis of granulosa in healthy growing oocyte and in resorbing atretic follicles. In this respect, the involvement of apoptosis in Torpedo marmorata oogenesis closely parallels that found in mammals, thus confirming that strategies of germ cell selection among vertebrates have been evolutionarily preserved., (Copyright 2003 Wiley-Liss, Inc.)
- Published
- 2003
- Full Text
- View/download PDF