1. The role of the p53 tumor suppressor in metabolism and diabetes.
- Author
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Kung CP and Murphy ME
- Subjects
- Amino Acid Substitution, Animals, Diabetes Mellitus, Type 1 physiopathology, Diabetes Mellitus, Type 2 genetics, Diabetes Mellitus, Type 2 physiopathology, Genetic Predisposition to Disease, Humans, Insulin metabolism, Insulin Resistance, Insulin Secretion, Insulin-Secreting Cells metabolism, Insulin-Secreting Cells pathology, Liver metabolism, Muscle, Skeletal metabolism, Pancreas pathology, Pancreas physiopathology, Polymorphism, Single Nucleotide, Prediabetic State genetics, Prediabetic State physiopathology, Tumor Suppressor Protein p53 chemistry, Tumor Suppressor Protein p53 genetics, Apoptosis, Diabetes Mellitus, Type 1 metabolism, Diabetes Mellitus, Type 2 metabolism, Models, Biological, Pancreas metabolism, Prediabetic State metabolism, Tumor Suppressor Protein p53 metabolism
- Abstract
In the context of tumor suppression, p53 is an undisputedly critical protein. Functioning primarily as a transcription factor, p53 helps fend off the initiation and progression of tumors by inducing cell cycle arrest, senescence or programmed cell death (apoptosis) in cells at the earliest stages of precancerous development. Compelling evidence, however, suggests that p53 is involved in other aspects of human physiology, including metabolism. Indeed, recent studies suggest that p53 plays a significant role in the development of metabolic diseases, including diabetes, and further that p53's role in metabolism may also be consequential to tumor suppression. Here, we present a review of the literature on the role of p53 in metabolism, diabetes, pancreatic function, glucose homeostasis and insulin resistance. Additionally, we discuss the emerging role of genetic variation in the p53 pathway (single-nucleotide polymorphisms) on the impact of p53 in metabolic disease and diabetes. A better understanding of the relationship between p53, metabolism and diabetes may one day better inform the existing and prospective therapeutic strategies to combat this rapidly growing epidemic., Competing Interests: Declaration of Interest The authors declare there are no conflicts of interest., (© 2016 Society for Endocrinology.)
- Published
- 2016
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