1. Adipokine adiponectin is a potential protector to human bronchial epithelial cell for regulating proliferation, wound repair and apoptosis: comparison with leptin and resistin.
- Author
-
Zhu XL, Qin XQ, Xiang Y, Tan YR, Qu XP, and Liu HJ
- Subjects
- Adiponectin, Asthma metabolism, Asthma physiopathology, Bronchi cytology, Bronchi metabolism, Calcium metabolism, Epithelial Cells cytology, Epithelial Cells metabolism, Humans, Leptin administration & dosage, Obesity metabolism, Reactive Oxygen Species metabolism, Resistin administration & dosage, Wound Healing, Apoptosis, Asthma complications, Calcium Signaling, Cell Proliferation drug effects, Obesity complications
- Abstract
Epidemiological data indicate an increasing incidence of asthma in the obese individuals recent decades, while very little is known about the possible association between them. Here, we compared the roles of adipocyte-derived factors, including leptin, adiponectin and resistin on proliferation, wound repair and apoptosis in human bronchial epithelial cells (HBECs) which play an important role in the pathogenesis of asthma. The results showed that exogenous globular adiponectin (gAd) promoted proliferation, cell-cycle and wound repair of HBECs. This effect may be relevant to Ca(2+)/calmodulin signal pathway. Besides, gAd inhibited apoptosis induced by ozone and release of lactate dehydrogenase (LDH) of HBECs via regulated adipoR1 and reactive oxygen species. No effects of leptin or resistin on proliferation, wound repair and apoptosis of HBECs were detectable. These data indicate that airway epithelium is the direct target of gAd which plays an important role in protecting HBECs from mechanical or oxidant injuries and may have therapeutic implications in the treatment of asthma., (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Published
- 2013
- Full Text
- View/download PDF