Search

Your search keyword '"Rakip U"' showing total 2 results
Start Over Author "Rakip U" Topic apoptosis
2 results on '"Rakip U"'

1. Cabazitaxel causes a dose-dependent central nervous system toxicity in rats.

Author

Karavelioglu E, Gonul Y, Aksit H, Boyaci MG, Karademir M, Simsek N, Guven M, Atalay T, and Rakip U

Subjects
Animals, Antineoplastic Agents administration & dosage, DNA Fragmentation drug effects, Dose-Response Relationship, Drug, Male, Neurons drug effects, Rats, Rats, Wistar, Taxoids administration & dosage, Antineoplastic Agents toxicity, Apoptosis drug effects, Brain drug effects, Central Nervous System drug effects, Taxoids toxicity
Abstract

Background: Chemotherapeutic agents may lead to serious neurological side effects, which in turn can deteriorate the quality of life and cause dose limiting. Direct toxic effect or metabolic derangement of chemotherapeutic agents may cause these complications. Cabazitaxel is a next generation semi-synthetic taxane derivative, which is effective in both preclinical models of human tumors sensitive or resistant to chemotherapy and in patients with progressive prostate cancer despite docetaxel treatment., Aim: The primary aim of this study was to investigate the central nervous system toxicity of Cabazitaxel. Secondary aim was to investigate the safety dose of Cabazitaxel for the central nervous system., Methods: A total of 24 adult male Wistar-Albino rats were equally and randomly divided into four groups as follows: group 1 (Controls), group 2 (Cabazitaxel 0.5mg/kg), group 3 (Cabazitaxel 1.0mg/kg) and group 4 (Cabazitaxel 1.5mg/kg). Cabazitaxel (Jevtana, Sanofi-Aventis USA) was intraperitoneally administered to groups 2, 3 and 4 at 0.5, 1.0 and 1.5mg/kg (body-weight/week) doses, respectively for four consecutive weeks. Beside this, group 1 received only i.p. saline at the same volume and time. At the end of the study, animals were sacrificed and bilateral brain hemispheres were removed for biochemical, histopathological and immunohistochemical examinations., Results: Intraperitoneal administration of Cabazitaxel has exerted neurotoxic effect on rat brain. We have observed that biochemical and immunohistochemical results became worse in a dose dependent manner., Conclusion: Our findings have suggested that Cabazitaxel may be a neurotoxic agent and can trigger apoptosis in neuron cells especially at high doses., (Copyright © 2015 Elsevier B.V. All rights reserved.)

Published
2016
Full Text
View/download PDF

2. Effects of 2-Aminoethyl Diphenylborinate, a Modulator of Transient Receptor Potential and Orai Channels in Subarachnoid Hemorrhage: An Experimental Study

Author

Adem Aslan, Serhat Yildizhan, Serhat Korkmaz, Mehmet Gazi Boyaci, Halit Buğra Koca, Esra Aslan, Usame Rakip, Boyacı, M.G., Department of Neurosurgery, Afyonkarahisar Health Sciences University Faculty of Medicine, Afyonkarahisar, Turkey -- Rakip, U., Department of Neurosurgery, TCSB Niğde Ömer Halisdemir University Hospital, Niğde, Turkey -- Aslan, A., Department of Neurosurgery, Afyonkarahisar Health Sciences University Faculty of Medicine, Afyonkarahisar, Turkey -- Koca, H.B., Department of Biochemistry, Afyonkarahisar Health Sciences University Faculty of Medicine, Afyonkarahisar, Turkey -- Aslan, E., Department of Histology and Embryology, Afyonkarahisar Health Sciences University Faculty of Medicine, Afyonkarahisar, Turkey -- Korkmaz, S., Department of Neurosurgery, Afyonkarahisar Health Sciences University Faculty of Medicine, Afyonkarahisar, Turkey -- Yıldızhan, S., Department of Neurosurgery, Afyonkarahisar Health Sciences University Faculty of Medicine, Afyonkarahisar, Turkey, and 0-Belirlenecek

Subjects
Boron Compounds, Male, Subarachnoid hemorrhage, Apoptosis, Pharmacology, Cisterna magna, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cerebral vasospasm, medicine.artery, Malondialdehyde, Basilar artery, Medicine, Animals, Vasospasm, Intracranial, cardiovascular diseases, chemistry.chemical_classification, business.industry, Tumor Necrosis Factor-alpha, TRP channels, Glutathione peroxidase, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Vasospasm, medicine.disease, nervous system diseases, Disease Models, Animal, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, ComputingMethodologies_PATTERNRECOGNITION, chemistry, Vasoconstriction, 030220 oncology & carcinogenesis, Basilar Artery, Arterial blood, Surgery, sense organs, Neurology (clinical), InformationSystems_MISCELLANEOUS, Ca2+ channels, business, 2-Aminoethyl diphenylborate, 030217 neurology & neurosurgery, Orai channels
Abstract

PubMed ID: 30905651, Background: Cerebral vasospasm remains a serious problem affecting morbidity and mortality in patients with subarachnoid hemorrhage (SAH) during neurosurgery. We aimed to demonstrate the role of the transient receptor potential channel and other channels for Ca2+ in the etiology of cerebral vasospasm using 2-aminoethyl diphenylborinate (2-APB) and the effective dose range of an unstudied pharmacological agent, which can limit vasospasm. Methods: We performed an experimental study using 32 Sprague-Dawley rats divided into 4 groups: sham group (n = 8), SAH group (n = 8), 2-APB group (SAH rats intraperitoneally administered with 0.5 mg/kg 2-APB; n = 8), and 2-APB-2 group (SAH rats intraperitoneally administered with 2 mg/kg 2-APB; n = 8). The rats were sacrificed after 24 hours, and superoxide dismutase, glutathione peroxidase, malondialdehyde, tumor necrosis factor-?, and interleukin-1ß in the brain tissue and serum were measured. The histopathological investigation of brain tissue included measurement of the luminal diameter and wall thickness of the basilar artery (BA), and apoptotic cells in the hippocampus were counted after caspase staining. Results: Autologous arterial blood injection into the cisterna magna caused vasospasm in rats. 2-APB treatment increased the BA wall thickness and reduced the BA lumen diameter, inducing significant vascular changes. 2-APB also alleviated cell apoptosis at 24 hours after SAH. Conclusion: In experimental SAH in rats, 2-APB treatment increased the BA wall thickness and reduced the BA lumen diameter, inducing significant vascular changes. 2-APB also alleviated cell apoptosis at 24 hours after SAH. © 2019 Elsevier Inc.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results