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Background: Photodynamic therapy is an alternative treatment of muco-cutaneous tumors that uses a light source able to photoactivate a chemical compound that acts as a photosensitizer. The phthalocyanines append to a wide chemical class that encompasses a large range of compounds; out of them aluminium-substituted disulphonated phthalocyanine possesses a good photosensitizing potential., Results: The destructive effects of PDT with aluminium-substituted disulphonated phthalocyanine are achieved by induction of apoptosis in tumoral cells as assessed by flow cytometry analysis. Using protein microarray we evaluate the possible molecular pathways by which photodynamic therapy activates apoptosis in dysplastic oral keratinocytes cells, leading to the tumoral cells destruction. Among assessed analytes, Bcl-2, P70S6K kinase, Raf-1 and Bad proteins represent the apoptosis related biomolecules that showed expression variations with the greatest amplitude., Conclusions: Up to date, the intimate molecular apoptotic mechanisms activated by photodynamic therapy with this type of phthalocyanine in dysplastic human oral keratinocytes are not completely elucidated. With protein microarray as high-throughput proteomic approach a better understanding of the manner in which photodynamic therapy leads to tumoral cell destruction can be obtained, by depicting apoptotic molecules that can be potentially triggered in future anti-tumoral therapies.

Incontinentia pigmenti (IP) is a complex genodermatosis inherited in an X-linked dominant pattern, associating multistadial cutaneous manifestations with an oculo-dento-cerebral syndrome, which affects only female newborns, as the disorder is lethal in males since intrauterine period. We report on a case of incontinentia pigmenti with an atypical debut consisting of tonic-clonic seizures which had started during the first days of life, associated with severe ocular and neurologic manifestations. The presence and severity of extra-cutaneous features most often command the evolution and the prognosis of the disease. [ABSTRACT FROM AUTHOR]

Photodynamic therapy (PDT) is a recent acquisition in the treatment of cutaneous premalignant and malignant lesions, based upon the administration or induction of the synthesis of a photosensitizer in the tumoral tissue, followed by the illumination of the target area using a radiation with an adequate wavelength. This paper aims to review the main molecular, cellular and systemic mechanistic aspects involved in the in vivo effects of PDT, with emphasis on apoptosis and autophagy induction in tumoral cells, local vascular destruction and immune response alteration. [ABSTRACT FROM AUTHOR]

Photodynamic therapy (PDT) is a recent acquisition in the treatment of cutaneous premalignant and malignant lesions, based upon the administration or induction of the synthesis of a photosensitizer in the tumoral tissue, followed by the illumination of the target area using a radiation with an adequate wavelength. This paper aims to review the main molecular, cellular and systemic mechanistic aspects involved in the in vivo effects of PDT, with emphasis on apoptosis and autophagy induction in tumoral cells, local vascular destruction and immune response alteration. [ABSTRACT FROM AUTHOR]