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Start Over Author "Ishkov Y" Topic applied microbiology and biotechnology
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1. Characteristics of the Pseudomonas aeruginosa PA01 intercellular signaling pathway (quorum sensing) functioning in presence of porphyrins bismuth complexes

Author

Galkin, M., Ivanitsia, V., Ishkov, Y., Galkin, B., and Tetiana Filipova

Subjects
Microbiology (medical), Porphyrins, Molecular Structure, Pseudomonas aeruginosa, Quorum Sensing, General Medicine, Bismuth, Applied Microbiology and Biotechnology, Microbiology, Anti-Bacterial Agents
Abstract

The influence of synthetic and natural porphyrins bismuth complexes on P. aeruginosa quorum sensing system was carried out by detection of the pyocyanin, rhamnolipids and autoinducers biosynthesis level. The highest ability to reduce pyocyanin biosynthesis showed Bi(III)-TPP. Rhamnolipids production level also decreased in the presence of studied compounds. This effect was the most expressed in presence of 40 and 80 µM of the synthetic meso-substituted porphyrins. Autoinducers biosynthesis, especially 3-oxo-C12-HSL was suppressed in presence of the bismuth complexes. That suggest that the mechanisms of action of this substances is an inhibition of signaling molecules or/and receptor for them.

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