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Your search keyword '"Zhongnan Yang"' showing total 2 results
Start Over Author "Zhongnan Yang" Topic arabidopsis thaliana
2 results on '"Zhongnan Yang"'

1. AtPID: Arabidopsis thaliana protein interactome database an integrative platform for plant systems biology

Author

Peng Li, Yuhua Li, Feng Xu, Yixue Li, Qingbo Yu, Guang Wang, Tieliu Shi, Guang Li, Chen Zhao, Jian Cui, and Zhongnan Yang

Subjects
Internet, Database, Arabidopsis Proteins, Systems biology, Protein domain, Arabidopsis, Computational Biology, Articles, Biology, biology.organism_classification, computer.software_genre, Databases, Bibliographic, Interactome, Genome, Systems Integration, User-Computer Interface, Protein Interaction Mapping, Genetics, Arabidopsis thaliana, Protein–protein interaction prediction, KEGG, Databases, Protein, computer
Abstract

Arabidopsis thaliana Protein Interactome Database (AtPID) is an object database that integrates data from several bioinformatics prediction methods and manually collected information from the literature. It contains data relevant to protein-protein interaction, protein subcellular location, ortholog maps, domain attributes and gene regulation. The predicted protein interaction data were obtained from ortholog interactome, microarray profiles, GO annotation, and conserved domain and genome contexts. This database holds 28,062 protein-protein interaction pairs with 23,396 pairs generated from prediction methods. Among the rest 4666 pairs, 3866 pairs of them involving 1875 proteins were manually curated from the literature and 800 pairs were from enzyme complexes in KEGG. In addition, subcellular location information of 5562 proteins is available. AtPID was built via an intuitive query interface that provides easy access to the important features of proteins. Through the incorporation of both experimental and computational methods, AtPID is a rich source of information for system-level understanding of gene function and biological processes in A. thaliana. Public access to the AtPID database is available at http://atpid.biosino.org/.

Published
2007

2. The Putative RNA-Dependent RNA Polymerase RDR6 Acts Synergistically with ASYMMETRIC LEAVES1 and 2 to Repress BREVIPEDICELLUS and MicroRNA165/166 in Arabidopsis Leaf Development.

Author

Hong Li, Lin Xu, Hua Wang, Zheng Yuan, Xiaofeng Cao, Zhongnan Yang, Dabing Zhang, Yuquan Xu, and Hai Huanga

Subjects
LEAF development, ARABIDOPSIS thaliana, PLANT development, PLANT genetics, PLANT physiology & genetics
Abstract

The Arabidopsis thaliana ASYMMETRIC LEAVES1 (AS1) and AS2 genes are important for repressing class I KNOTTED1-like homeobox (KNOX) genes and specifying leaf adaxial identity in leaf development. RNA-dependent RNA polymerases (RdRPs) are critical for posttranscriptional and transcriptional gene silencing in eukaryotes; however, very little is known about their functions in plant development. Here, we show that the Arabidopsis RDR6 gene (also called SDE1 and SGS2) that encodes a putative RdRP, together with AS1 and AS2, regulates leaf development, rdr6 single mutant plants displayed only minor phenotypes, whereas rdr6 as1 and rdr6 as2 double mutants showed dramatically enhanced as1 and as2 phenotypes, with severe defects in the leaf adaxial-abaxial polarity and vascular development. In addition, the double mutant plants produced more lobed leaves than the as1 and as2 single mutants and showed leaf-like structures associated on a proportion of leaf blades. The abnormal leaf morphology of the double mutants was accompanied by an extended ectopic expression of a class I KNOX gene BREVIPEDICELLUS (BP) and high levels of microRNA165/166 that may lead to mRNA degradation of genes in the class III HD-ZIP family. Taken together, our data suggest that the Arabidopsis RDR6-associated epigenetic pathway and the AS1-AS2 pathway synergistically repress BP and MIR165/166 for proper plant development. [ABSTRACT FROM AUTHOR]

Published
2005

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