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5 results on '"Azza Al-Mujalli"'

1. The prevalence of metabolic syndrome in patients receiving antipsychotics in Qatar: a cross sectional comparative study

Author

Samer Hammoudeh, Suhaila Ghuloum, Ziyad Mahfoud, Arij Yehya, Abdulmoneim Abdulhakam, Azza Al-Mujalli, Mahmoud Al-Zirie, Mohamed Osman Abdel Rahman, Angela Godwin, Noura Younes, Yahya Hani, Dennis Mook-Kanamori, Marjonneke Mook-Kanamori, Reem El Sherbiny, and Hassen Al-Amin

Subjects
Metabolic syndrome, Antipsychotics, Arabs, Mental illness, Psychiatry, RC435-571
Abstract

Abstract Background Metabolic abnormalities are common in patients maintained on antipsychotics. These abnormalities increase the risk of cardiovascular diseases and mortality in this population. The aim of this study is to assess the prevalence of metabolic syndrome (MetS) in subjects maintained on antipsychotics relative to controls in Qatar, and to assess the factors contributing to the development of MetS. Methods A cross sectional design was used to collect data and fasting blood samples from subjects maintained on antipsychotics for at least six months (n = 112) and from a control group (n = 114). The groups were compared in regard to prevalence of MetS, and multiple regression analysis was used to determine the risk factors in each group. Results The two groups (antipsychotics vs. control) were similar in regard to age (35.73 ± 10.28 vs. 35.73 ± 8.16 years) and gender ratio. The MetS was higher among the subjects on antipsychotics, but this difference did not reach statistical significance. Blood pressure (BP) was significantly higher in the antipsychotics group and BMI was the major risk factor to develop MetS in this group. Conclusions The prevalence of MetS in both groups is high and mostly attributed to obesity and high BP. Public health interventions are needed to address this major health problem overall. Larger studies are needed to further assess the impact of antipsychotics and mental illness on the development of MetS.

Published
2018
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2. Validation of the Arabic Version of Calgary Depression Scale for Schizophrenia

Author

Mark Opler, Ziyad Mahfoud, Suhaila Ghuloum, Azza Al-Mujalli, Samer Hammoudeh, Reem Elsherbiny, Anzalee Khan, Yahya Hani, Abdulmoneim Abdulhakam, Arij Yehya, and Hassen Al-Amin

Subjects
Male, Research Validity, Psychometrics, lcsh:Medicine, Social Sciences, Geographical Locations, 0302 clinical medicine, Mathematical and Statistical Techniques, Medicine and Health Sciences, Medicine, Ethnicities, Psychology, 030212 general & internal medicine, lcsh:Science, Depression (differential diagnoses), Principal Component Analysis, Multidisciplinary, Depression, Research Assessment, Middle Aged, Arabs, Suicide, Schizophrenia, Physical Sciences, language, Female, Statistics (Mathematics), Research Article, Adult, medicine.medical_specialty, Asia, Arabic, Depression scale, Research and Analysis Methods, behavioral disciplines and activities, 03 medical and health sciences, Cronbach's alpha, mental disorders, Mental Health and Psychiatry, Humans, Statistical Methods, Psychiatry, Qatar, Mini-international neuropsychiatric interview, business.industry, Mood Disorders, lcsh:R, Biology and Life Sciences, Reproducibility of Results, medicine.disease, language.human_language, 030227 psychiatry, People and Places, Multivariate Analysis, lcsh:Q, Population Groupings, business, Mathematics, Diagnosis of schizophrenia
Abstract

Background Patients with schizophrenia commonly show both depressive and negative symptoms that can differentially affect the prognosis and course of treatment. The Calgary Depression Scale for Schizophrenia (CDSS) was designed to distinguish between depression and negative symptoms in patients with schizophrenia. The purpose of this study is to validate an Arabic version of the CDSS among patients with schizophrenia. Methods The diagnosis of schizophrenia was confirmed using the Arabic Mini International Neuropsychiatric Interview 6 (MINI 6). A standardized translation back-translation process was adopted. One rater administered the Arabic CDSS to subjects with schizophrenia as well as to a control group who should not have any psychiatric disorder except for depression. Another rater, blinded to the results administered the already validated Arabic version of Beck Depression Inventory-II (BDI-II). Results We recruited 102 patients and 102 controls subjects. The CDSS showed good internal consistency in the active group (Cronbach’s alpha = 0.82). The Intraclass Coefficient correlations (ICC) for the inter-rater reliability (n = 21) was 0.90, p

Published
2016

3. Validity and Reliability of the Arabic Version of the Positive and Negative Syndrome Scale

Author

Suhaila Ghuloum, Anzalee Khan, Reem Elsherbiny, Samer Hammoudeh, Ziyad Mahfoud, Abdulmoneim Abdulhakam, Hassen Al-Amin, Arij Yehya, Yahya Hani, Azza Al-Mujalli, and Mark Opler

Subjects
Adult, Male, medicine.medical_specialty, Validity, Sensitivity and Specificity, 03 medical and health sciences, Young Adult, 0302 clinical medicine, medicine, Humans, Psychiatry, Reliability (statistics), Mini-international neuropsychiatric interview, Language, Observer Variation, Positive and Negative Syndrome Scale, Construct validity, Reproducibility of Results, Middle Aged, Translating, medicine.disease, Self Concept, 030227 psychiatry, Arabs, Psychiatry and Mental health, Clinical Psychology, Inter-rater reliability, Psychotic Disorders, Schizophrenia, Female, Schizophrenic Psychology, Psychology, 030217 neurology & neurosurgery, Diagnosis of schizophrenia
Abstract

Background: The Positive and Negative Syndrome Scale (PANSS) is widely used for patients with schizophrenia. This scale is reliable and valid. The PANSS was translated and validated in several languages. Objective: The aim of this study was to translate and validate the PANSS in the Arab population. Subjects and Methods: The PANSS was translated into formal Arabic language using the back-translation method. 101 Arab patients with schizophrenia and 98 Arabs with no diagnosis of any mental disorder were recruited. The Arabic version of the Mini International Neuropsychiatric Interview (MINI-6) was used as a diagnostic tool to confirm the diagnosis of schizophrenia or rule out any diagnosis for the healthy control group. Reliability of the scale was assessed by calculating internal consistency, interrater reliability and test-retest reliability. Construct validity was assessed using the Arabic version of the MINI-6. PANSS total scores were correlated with the Clinical Global Impression-Severity scale. Results: Our findings showed that the internal consistency was good (0.92). Scores on the PANSS of the patients were much higher than those of the healthy controls. The PANSS showed good interrater reliability and test-retest reliability (0.92 and 0.75, respectively). In comparison with the MINI-6, the PANSS showed good sensitivity and specificity, which implies good construct validity of this version. Conclusion: In conclusion, the Arabic version of the PANSS is a reliable and valid instrument for the assessment of patients with schizophrenia in the Arab population.

Published
2016

4. Reliability, validity and factorial structure of the Arabic version of the international suicide prevention trial (InterSePT) scale for suicidal thinking in schizophrenia patients in Doha, Qatar

Author

Hassen Al-Amin, Anzalee Khan, Arij Yehya, Suhaila Ghuloum, Abdulmoneim Abdulhakam, Samer Hammoudeh, Ziyad Mahfoud, Azza Al-Mujalli, Mark Opler, Reem Elsherbiny, and Yahya Hani

Subjects
Adult, Male, Suicide Prevention, medicine.medical_specialty, Psychometrics, Schizophrenia (object-oriented programming), Suicide scales, Population, Suicidality, Suicide prevention, Suicidal Ideation, 03 medical and health sciences, Middle East, 0302 clinical medicine, Cronbach's alpha, Surveys and Questionnaires, medicine, Humans, Translations, Psychiatry, education, Suicidal ideation, Qatar, Mini-international neuropsychiatric interview, Psychiatric Status Rating Scales, education.field_of_study, Gold standard, Reproducibility of Results, Translating, 030227 psychiatry, Arabs, Suicide, Psychiatry and Mental health, Scale (social sciences), Schizophrenia, Female, Schizophrenic Psychology, medicine.symptom, Psychology, 030217 neurology & neurosurgery, Clinical psychology, Research Article
Abstract

Background Patients with schizophrenia are known to have higher rates of mortality and morbidity when compared to the general population. Suicidality is a major contributor to increased mortality. The International Suicide Prevention Trial (InterSePT) Scale for Suicidal Thinking (ISST) is a validated tool to assess current suicidal ideation in patients with schizophrenia. The aims of the study were to culturally adapt the Arabic translation of ISST and to examine the psychometric characteristics of the Arabic version of the ISST among patients with schizophrenia in Qatar. Methods ISST was translated and adapted into formal Arabic using the back translation method. Patients diagnosed with schizophrenia were randomly recruited from the department of Psychiatry, Rumailah Hospital, Doha, Qatar. Healthy controls were randomly recruited from two primary health care centers in Doha, Qatar. The Arabic version of Module B for suicidality in Mini International Neuropsychiatric Interview was used as the gold standard to which the Arabic ISST was compared. Results The study sample (n = 199) was composed of 100 patients diagnosed with schizophrenia (age 35.30 ± 10.04 years; M/F is 2/1) and 99 controls (age 33.98 ± 8.33 years; M/F is 2/3). The mean score on the ISST was 3.03 ± 4.75 vs. 0.47 ± 1.44 for the schizophrenia and control groups, respectively. Inter-rater reliability coefficient was 0.95, p > 0.001. The overall Cronbach’s alpha was 0.92. Principal Component Analysis produced 3 factors explaining a total of 73.8% of variance. Conclusions This is the first study in the Arab countries to validate the Arabic version of the ISST. The psychometric properties indicate that the Arabic ISST is a valid tool to assess the severity of suicidal ideation in Arabic patients with schizophrenia.

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5. Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population

Author

Albert B. Lowenfels, Hekmat A Rouh, Mona Taher Aseel, Ramzi Temanni, Dhanya Kizhakayil, Sara Tomei, Ravinder Mamtani, Ahmed Abdelkerim, Naser Elkum, Sura Al-Samraye, Al-Anood Al-Thani, Ena Wang, Idil I. Aigha, Maryam Abdulmalik, Francesco M. Marincola, Awatef Ismail, Lotfi Chouchane, Emad El Sebakhy, Javaid I. Sheikh, Fatima Hani, Rashid Al Ali, Siddik Youssif, Mohammed Al-Thani, Sohaila Cheema, Azza Al Mujalli, Nada El Emadi, Andrea Worschech, and Vineesh Khanna

Subjects
Adult, Male, Genotyping, Population, Physiology, Consanguinity, Overweight, Biology, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Body Mass Index, Thinness, Single Nucleotide Polymorphism (SNP), Polymorphism (computer science), Genotype, medicine, Humans, Genetic Predisposition to Disease, Obesity, Allele, education, Qatar, Genetics, Medicine(all), Principal Component Analysis, education.field_of_study, Biochemistry, Genetics and Molecular Biology(all), Research, Racial Groups, General Medicine, Middle Aged, medicine.disease, Arabs, Logistic Models, Phenotype, Genetic Loci, Female, medicine.symptom, Body mass index
Abstract

Objectives In Qataris, a population characterized by a small size and a high rate of consanguinity, between two-thirds to three-quarters of adults are overweight or obese. We investigated the relevance of 23 obesity-related loci in the Qatari population. Methods Eight-hundred-four individuals assessed to be third generation Qataris were included in the study and assigned to 3 groups according to their body mass index (BMI): 190 lean (BMI

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