1. [The role of modification of fatty acid composition of erythrocyte lipids in pathogenesis of arterial hypertension].
- Author
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Karaman IuK, Novgorodtseva TP, Kantur TA, Antoniuk MV, and Zhukova NV
- Subjects
- 8,11,14-Eicosatrienoic Acid analysis, 8,11,14-Eicosatrienoic Acid metabolism, Arachidonic Acid analysis, Atherosclerosis metabolism, Biological Transport, Active physiology, Chromatography, Gas, Female, Humans, Hyperlipidemias blood, Hyperlipidemias complications, Hypertension etiology, Inflammation Mediators metabolism, Lipoproteins blood, Male, Middle Aged, Palmitic Acid analysis, Vasoconstriction physiology, 8,11,14-Eicosatrienoic Acid analogs & derivatives, Arachidonic Acid metabolism, Carbon-Carbon Double Bond Isomerases analysis, Carbon-Carbon Double Bond Isomerases deficiency, Carbon-Carbon Double Bond Isomerases metabolism, Erythrocyte Membrane physiology, Hypertension blood, Palmitic Acid metabolism
- Abstract
We used liquid chromatography for analysis of fatty acids (FA) in lipids of erythrocytes of patients with hypertensive disease (HD) with normo- (group 1) and hyperlipidemia (group 2). Abnormalities of FA composition of erythrocyte lipids were revealed in both groups. In group 1 we found deficit of polyenic acids of omega-6 family, accumulation of Mead acid - prostanoid precursor with pronounced vasoconstrictor and pro inflammatory properties. In group 2 we noted more profound rearrangement of lipid matrix of erythrocyte membrane manifested as deficiency of omega-3 polyenic acids, accumulation of palmitinic and arachidonic acids. Preponderance of saturated FA in erythrocytes and deficiency of polyenic acids might evidence for pathology of their ligand-receptor transport into the cell. Blockade of active FA transport initiates formation of HD, promotes accumulation of atherogenic fractions of lipoproteins in blood. These results evidence for important pathogenetic role of FA in development of hypertension.
- Published
- 2010