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LunAres Research Station is an analog research station for crewed space mission simulation, located at the abandoned airport in Poland. The facility provides full isolation, allowing for complex research on the psychological and physiological impact of long-term extra-terrestrial human presence. The general objective of LunAres is to create a research platform to support scientific and technological development in human space exploration. A broad range of specialists is involved in the study from fields like extreme medicine, psychology, biotechnology, robotics and engineering, sociology, architecture. The possible observation and control of the indoor environment, as well as telemetry of the crew's physical and psychological states, provide large quantities of data for complex studies. This paper presents an overview of the LunAres Research Station activity since its establishment in 2017. The contribution to scientific research and technology development is included. Based on the presented experience of carried missions and crews' feedback a roadmap regarding the station design advancement is determined. The decision-making process of development is presented finalized with the demonstration of the potential for future projects and studies regarding human missions and sustainability. The conclusions of upgraded functional plans and spaces were determined through research on existing references and the new strategy for LunAres. Detailed drawings regarding architectural and technical solutions as well as future steps will be introduced. • LunAres Research Station gathered feedback on infrastructure during conducted manned missions. • Analog missions can have a significant impact on pursuing SDG on Earth • Analog missions have can investigate the impacts of isolation during pandemic. • Human and environmental telemetry studies are essential for space missions. [ABSTRACT FROM AUTHOR]