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Your search keyword '"Valdes Roberto Bolella"' showing total 3 results
Start Over Author "Valdes Roberto Bolella" Topic arctic medicine. tropical medicine
3 results on '"Valdes Roberto Bolella"'

1. Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the 'Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions'.

Author

Maria Aparecida Shikanai-Yasuda, Mauro Felippe Felix Mediano, Christina Terra Gallafrio Novaes, Andréa Silvestre de Sousa, Ana Marli Christovam Sartori, Rodrigo Carvalho Santana, Dalmo Correia, Cleudson Nery de Castro, Marilia Maria Dos Santos Severo, Alejandro Marcel Hasslocher-Moreno, Marisa Liliana Fernandez, Fernando Salvador, Maria Jesús Pinazo, Valdes Roberto Bolella, Pedro Carvalho Furtado, Marcelo Corti, Ana Yecê Neves Pinto, Alberto Fica, Israel Molina, Joaquim Gascon, Pedro Albajar Viñas, Juan Cortez-Escalante, Alberto Novaes Ramos, and Eros Antonio de Almeida

Subjects
Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
Abstract

ObjectiveChagas disease (CD) globalization facilitated the co-infection with Human Immunodeficiency Virus (HIV) in endemic and non-endemic areas. Considering the underestimation of Trypanosoma cruzi (T. cruzi)-HIV co-infection and the risk of life-threatening Chagas Disease Reactivation (CDR), this study aimed to analyze the major co-infection clinical characteristics and its mortality rates.MethodsThis is a cross-sectional retrospective multicenter study of patients with CD confirmed by two serological or one parasitological tests, and HIV infection confirmed by immunoblot. CDR was diagnosed by direct microscopy with detection of trypomastigote forms in the blood or other biological fluids and/or amastigote forms in inflammatory lesions.ResultsOut of 241 patients with co-infection, 86.7% were from Brazil, 47.5% had ConclusionThis study showed major features on T. cruzi-HIV co-infection and highlighted the prognostic role of CD4+ cells for reactivation and mortality. Since lethality was high in meningoencephalitis and all untreated patients died shortly after the diagnosis, early diagnosis, immediate antiparasitic treatment, patient follow-up and epidemiological surveillance are essentials in T. cruzi/HIV co-infection and CDR managements.

Published
2021
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2. Cutaneous and articular tuberculosis in a renal transplant recipient

Author

Miguel Moyses-Neto, Daniel Drumond, Giuliano Morgantetti, Tania Maria Pisi Garcia, Valdes Roberto Bolella, and Elen Almeida Romao

Subjects
Cutaneous tuberculosis, Articular tuberculosis, Kidney transplant, Arctic medicine. Tropical medicine, RC955-962
Abstract

Abstract Seven months after undergoing kidney transplantation, a 56-year-old woman presented with papules and ulcers in her right forearm. The patient received antibiotics for 8 months with limited improvement. Eleven months after symptom onset, she presented with acute arthritis in her left knee. Asynovial fluid culture yielded Mycobacterium tuberculosis, and a forearm ulcer biopsy showed granulomatous inflammation. After surgical fistulectomy and 12 months of tuberculosis treatment, she was cured. Chronic cutaneous ulcers and articular manifestations in TB are rare, but they should always be considered in the differential diagnosis for immunosuppressed patients. Surgical intervention and prolonged treatment might be necessary.

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3. Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the 'Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions'

Author

Marilia Maria dos Santos Severo, Christina Terra Gallafrio Novaes, Marcelo Corti, Mauro Felippe Felix Mediano, Cleudson Castro, Pedro Albajar Viñas, Ana Marli Christovam Sartori, Juan José Cortez-Escalante, Dalmo Correia, Pedro Carvalho Furtado, María-Jesús Pinazo, Rodrigo de Carvalho Santana, Valdes Roberto Bolella, Fernando Salvador, Israel Molina, Maria Aparecida Shikanai-Yasuda, Joaquim Gascon, Alberto Fica, Andréa Silvestre de Sousa, Alejandro Marcel Hasslocher-Moreno, Alberto Novaes Ramos, Eros Antonio de Almeida, Ana Yecê das Neves Pinto, Marisa Liliana Fernandez, Institut Català de la Salut, [Shikanai-Yasuda MA] Departament of Infectious and Parasitic, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil. Laboratory of Immunology, Hospital das Clínicas, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil. WHO Technical Group IVb on prevention, control and management of non congenital infections of the Global Network for Chagas Disease Elimination, WHO, Geneva, Switzerland. [Mediano MFF, Sousa AS] Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Health Ministry, Rio de Janeiro, Brazil. [Novaes CTG, Sartori AMC] Division of Infectious Diseases, Hospital das Clínicas, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil. [Santana RC] Division of Infectious Diseases, Department of Internal Medicine, Ribeirão Preto Medical School University of São Paulo, Ribeirão Preto, Brazil. [Salvador F, Molina I] Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. PROSICS, Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
CD4-Positive T-Lymphocytes, Male, virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIH [ENFERMEDADES], medicine.medical_treatment, RC955-962, HIV Infections, técnicas de investigación::métodos epidemiológicos::recopilación de datos::estadísticas vitales::mortalidad [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Serology, enfermedades parasitarias::infecciones por protozoos::infecciones por Euglenozoa::tripanosomiasis::enfermedad de Chagas [ENFERMEDADES], Medical Conditions, Infectious Diseases of the Nervous System, Meningoencephalitis, Antiparasitic Therapy, Arctic medicine. Tropical medicine, Medicine and Health Sciences, Public and Occupational Health, Data Management, Protozoans, biology, Coinfection, Eukaryota, HIV diagnosis and management, Immunosuppression, Middle Aged, Viral Load, Vaccination and Immunization, Infectious Diseases, Neurology, Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Female, Public aspects of medicine, RA1-1270, Viral load, Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Trypanosomiasis::Chagas Disease [DISEASES], Brazil, Research Article, Neglected Tropical Diseases, Chagas disease, Adult, Trypanosoma, Myocarditis, Infeccions per VIH - Mortalitat, Trypanosoma cruzi, Immunology, Viral diseases, Acquired immunodeficiency syndrome (AIDS), parasitic diseases, Parasitic Diseases, medicine, Chagas, Malaltia de - Mortalitat, Humans, Chagas Disease, Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections [DISEASES], Retrospective Studies, Immunosuppression Therapy, Acquired Immunodeficiency Syndrome, Protozoan Infections, business.industry, Organisms, Public Health, Environmental and Occupational Health, Biology and Life Sciences, Tropical Diseases, medicine.disease, biology.organism_classification, Diagnostic medicine, Parasitic Protozoans, CD4 Lymphocyte Count, Cross-Sectional Studies, Co-Infections, Preventive Medicine, business, Delivery of Health Care
Abstract

Objective Chagas disease (CD) globalization facilitated the co-infection with Human Immunodeficiency Virus (HIV) in endemic and non-endemic areas. Considering the underestimation of Trypanosoma cruzi (T. cruzi)-HIV co-infection and the risk of life-threatening Chagas Disease Reactivation (CDR), this study aimed to analyze the major co-infection clinical characteristics and its mortality rates. Methods This is a cross-sectional retrospective multicenter study of patients with CD confirmed by two serological or one parasitological tests, and HIV infection confirmed by immunoblot. CDR was diagnosed by direct microscopy with detection of trypomastigote forms in the blood or other biological fluids and/or amastigote forms in inflammatory lesions. Results Out of 241 patients with co-infection, 86.7% were from Brazil, 47.5% had, Author summary Chagas disease (CD) is a chronic infectious disease caused by the parasite T. cruzi that accounts for a major burden due to its life-lasting morbidity in endemic and non-endemic areas. Globalization facilitated the meeting of CD and Human Immunodeficiency Virus (HIV) infection (T. cruzi/HIV co-infection). Patients with this co-infection are at risk of life-threatening CDR. This study aimed to analyze the clinical characteristics and mortality rates of patients with T. cruzi/HIV co-infection. This retrospective multicenter study included 241 patients with co-infection, of those 60 with CDR. Death was more frequent in patients with reactivation and was mainly caused by CDR. Our data showed that co-infection diagnosis is close to the reactivation diagnosis and characterized by poor immune response associated to CDR, higher lethality and more severe forms of CDR (meningoencephalitis). This study emphasizes the prognostic role of CD4+ cells on reactivation and mortality and the need of epidemiological surveillance for co-infection and CDR.

Published
2021

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