1. Role of immune mediators in predicting hospitalization of SARS-CoV-2 positive patients
- Author
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S. Ashrafzadeh-Kian, M.R. Campbell, J.C. Jara Aguirre, J. Walsh, A. Kumanovics, G. Jenkinson, P. Rinaldo, M.R. Snyder, and A. Algeciras-Schimnich
- Subjects
Male ,LLOQ, Lower Limit of Quantification ,AMR, Analytic Measuring Range ,VEGF, Vascular endothelial growth factor ,G-CSF, Granulocyte colony-stimulating factor ,MIP-1α, Macrophage inflammatory protein 1α ,Biochemistry ,Severity of Illness Index ,MCP-1, Monocyte chemoattractant protein-1 ,Immunology and Allergy ,LIF, Leukemia inhibitory factor ,IL, Interleukin ,vWF-A2, von Willebrand factor A2 domain ,Hospital Mortality ,IM, Immune Mediator ,sIL-6Rα, Interleukin 6 receptor α (soluble) ,Immune mediator ,COVID-19, Coronavirus disease 2019 ,Hematology ,Middle Aged ,Prognosis ,EN-RAGE/S100A12, Extracellular newly identified receptor for advanced glycation end products binding protein ,Hospitalization ,C-Reactive Protein ,Treatment Outcome ,Multiplex assay ,Area Under Curve ,IL-6, Interleukin 6 ,Cytokines ,Female ,Receptors, Chemokine ,Chemokines ,IL-18, Interleukin 18 ,Adult ,PDGF, Platelet-derived growth factor ,CLIR, Collaborative Laboratory Integrated Reports ,Immunology ,Article ,Fibrin Fibrinogen Degradation Products ,IFNα, IFNβ, IFNγ, Interferon α, β, γ ,Humans ,Receptors, Cytokine ,Molecular Biology ,IL-6 ,IL-10, Interleukin 10 ,Interleukin-6 ,SARS-CoV-2 ,COVID-19 ,IP-10, CXCL-10, Interferon gamma-induced protein 10 ,Length of Stay ,IL-1β, Interleukin 1 beta ,Respiration, Artificial ,SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2 ,ROC Curve ,TNF, TNF-α, Tumor necrosis factor-alpha ,Ferritins ,GM-CSF, Granulocyte-macrophage colony-stimulating factor ,sIL-2Rα, Interleukin 2 receptor α (soluble) ,Biomarkers ,FGF, Fibroblast growth factor - Abstract
Background Several immune mediators (IM) including cytokines, chemokines, and their receptors have been suggested to play a role in COVID-19 pathophysiology and severity. Aim To determine if early IM profiles are predictive of clinical outcome and which of the IMs tested possess the most clinical utility. Methods A custom bead-based multiplex assay was used to measure IM concentrations in a cohort of SARS-CoV-2 PCR positive patients (n = 326) with varying disease severities as determined by hospitalization status, length of hospital stay, and survival. Patient groups were compared, and clinical utility was assessed. Correlation plots were constructed to determine if significant relationships exist between the IMs in the setting of COVID-19. Results In PCR positive SARS-CoV-2 patients, IL-6 was the best predictor of the need for hospitalization and length of stay. Additionally, MCP-1 and sIL-2Rα were moderate predictors of the need for hospitalization. Hospitalized PCR positive SARS-CoV-2 patients displayed a notable correlation between sIL-2Rα and IL-18 (Spearman’s ρ = 0.48, P= more...
- Published
- 2021