1. Endothelial nitric oxide pathways in the pathophysiology of dengue: a prospective observational study
- Author
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Yacoub, S, Lam, PK, Huynh, TT, Ho, HH, Thi, HT, Van, NT, Lien, LT, Ha, QNT, Le, DHT, Mongkolspaya, J, Culshaw, A, Yeo, TW, Wertheim, H, Simmons, C, Screaton, G, Wills, B, National Institute for Health Research, Commission of the European Communities, Wellcome Trust, and GlaxoSmithKline Services Unlimited
- Subjects
Adult ,Male ,Adolescent ,Arginase ,11 Medical And Health Sciences ,06 Biological Sciences ,Arginine ,Nitric Oxide ,Microbiology ,dengue ,Young Adult ,endothelial function ,Humans ,Female ,l-arginine ,Endothelium, Vascular ,Prospective Studies ,Articles and Commentaries ,Biomarkers - Abstract
Endothelial dysfunction/reduced nitric oxide bioavailability is associated with worse plasma leakage in dengue patients and occurs early in the course of the disease. Endothelial dysfunction correlates with lower plasma l-arginine and higher arginase-1 levels., Background Dengue can cause increased vascular permeability that may lead to hypovolemic shock. Endothelial dysfunction may underlie this; however, the association of endothelial nitric oxide (NO) pathways with disease severity is unknown. Methods We performed a prospective observational study in 2 Vietnamese hospitals, assessing patients presenting early (
- Published
- 2017