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A convenient and efficient method is developed for the synthesis of 1,2,3,4,6‐pentasubstituted piperidines via a three‐component, one‐pot domino reaction of β‐ketoesters, aromatic aldehydes, and aromatic amines in the presence of a catalytic amount of saccharin in methanol at 40°C. The desired piperidines could be easily collected through simple filtration with excellent diastereoselectivities. [ABSTRACT FROM AUTHOR]

A simple, efficient and green approach to the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones has been developed via one-pot three-component reaction of aromatic aldehyde, malononitrile and phthalhydrazide catalyzed by zinc–proline complex (Zn[L-proline]2) using H2O: PEG400 = 6: 4 as solvent. Atom economy, good to excellent yield, operational simplicity and easy workup are important features of this method. [ABSTRACT FROM AUTHOR]

An efficient method for the synthesis of highly functionalized piperidines via one-pot domino reaction of β-ketoesters, aromatic aldehydes, and aromatic amines was reported. This multicomponent coupling was catalyzed by TMSI in methanol at room temperature, giving desired substituted pyridines in moderate to good yields. [ABSTRACT FROM AUTHOR]