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Herein, a direct, metal‐free, and site‐selective electrochemical C−H carboxylation of arenes by reductive activation using CO2 as the economic and abundant carboxylic source was reported. The electrocarboxylation was carried out in an operationally simple manner with high chemo‐ and regioselectivity, setting the stage for the challenging site‐selective C−H carboxylation of unactivated (hetero)arenes. The robust nature of the electrochemical strategy was reflected by a broad scope of substrates with excellent atom economy and unique selectivity. Notably, the direct and selective C−H carboxylation of various challenging arenes worked well in this approach, including electron‐deficient naphthalenes, pyridines, simple phenyl derivatives, and substituted quinolines. The method benefits from being externally catalyst‐free, metal‐free and base‐free, which makes it extremely attractive for potential applications. [ABSTRACT FROM AUTHOR]

Herein, a direct, metal‐free, and site‐selective electrochemical C−H carboxylation of arenes by reductive activation using CO2 as the economic and abundant carboxylic source was reported. The electrocarboxylation was carried out in an operationally simple manner with high chemo‐ and regioselectivity, setting the stage for the challenging site‐selective C−H carboxylation of unactivated (hetero)arenes. The robust nature of the electrochemical strategy was reflected by a broad scope of substrates with excellent atom economy and unique selectivity. Notably, the direct and selective C−H carboxylation of various challenging arenes worked well in this approach, including electron‐deficient naphthalenes, pyridines, simple phenyl derivatives, and substituted quinolines. The method benefits from being externally catalyst‐free, metal‐free and base‐free, which makes it extremely attractive for potential applications. [ABSTRACT FROM AUTHOR]

A direct metal-free, base-free, and site-selective electrochemical C-H carboxylation of arenes by reductive activation using CO SB 2 sb as an economic and abundant carboxyl source was developed. C-H Carboxylation, CO2 Valorization, Carbon Dioxide, Electroreduction, Selectivity Keywords: C-H Carboxylation; CO2 Valorization; Carbon Dioxide; Electroreduction; Selectivity EN C-H Carboxylation CO2 Valorization Carbon Dioxide Electroreduction Selectivity 1 1 1 01/11/23 20230116 NES 230116 B A site-selective electrochemical b C-H carboxylation of arenes with CO SB 2 sb is reported by Youai Qiu and co-workers in their Research Article (e202214710). [Extracted from the article]

Herein, a direct, metal‐free, and site‐selective electrochemical C−H carboxylation of arenes by reductive activation using CO2 as the economic and abundant carboxylic source was reported. The electrocarboxylation was carried out in an operationally simple manner with high chemo‐ and regioselectivity, setting the stage for the challenging site‐selective C−H carboxylation of unactivated (hetero)arenes. The robust nature of the electrochemical strategy was reflected by a broad scope of substrates with excellent atom economy and unique selectivity. Notably, the direct and selective C−H carboxylation of various challenging arenes worked well in this approach, including electron‐deficient naphthalenes, pyridines, simple phenyl derivatives, and substituted quinolines. The method benefits from being externally catalyst‐free, metal‐free and base‐free, which makes it extremely attractive for potential applications. [ABSTRACT FROM AUTHOR]

Herein, a direct, metal‐free, and site‐selective electrochemical C−H carboxylation of arenes by reductive activation using CO2 as the economic and abundant carboxylic source was reported. The electrocarboxylation was carried out in an operationally simple manner with high chemo‐ and regioselectivity, setting the stage for the challenging site‐selective C−H carboxylation of unactivated (hetero)arenes. The robust nature of the electrochemical strategy was reflected by a broad scope of substrates with excellent atom economy and unique selectivity. Notably, the direct and selective C−H carboxylation of various challenging arenes worked well in this approach, including electron‐deficient naphthalenes, pyridines, simple phenyl derivatives, and substituted quinolines. The method benefits from being externally catalyst‐free, metal‐free and base‐free, which makes it extremely attractive for potential applications. [ABSTRACT FROM AUTHOR]