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1. Die Wirkung einer Leberschädigung durch Thioacetamid auf die mikrosomale Aromatisierung von Testosteron bei der Ratte

Author

Bolt Hm and Del Pino Vl

Subjects
Pharmacology, medicine.medical_specialty, Chemistry, medicine.medical_treatment, Aromatization, Cell Biology, In vitro, Steroid, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Endocrinology, Internal medicine, medicine, Microsome, Molecular Medicine, Liberation, Tritium, Thioacetamide, Molecular Biology, Testosterone
Abstract

Rat liver microsomes, NADPH-regenerating system, and 1beta, 2beta-3H-testosterone have been incubated in vitro. The loss of tritium from the steroid, associated with aromatization of testosterone, was linear with time for 20 min and required NADPH. Pre-treatment of the rats with thioacetamide raised the liberation of tritium from 1beta, 2beta-3H-testosterone. The results suggest that liver damage by thioacetamide in rats may give rise to increased aromatization of testosterone.

Published
1976
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