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• Thyroid dysfunction is not associated with significantly higher rates of new-onset arrhythmias. • When developed, these arrhythmias are associated with higher mortality and resource utilization. • The patients admitted to the hospital should have thyroid function checked when found to have an arrhythmia. • Further studies are indicated with long-term follow up showing frequency of arrhythmias associated with thyroid dysfunction. Thyroid dysfunction has been associated with cardiovascular dysfunction in the literature. However, the frequency of new-onset arrhythmias associated with thyroid disease hospitalization is unknown. Hence, we analyzed frequency, in-hospital outcomes, and resource utilization of new-onset arrhythmias associated with thyroid dysfunction hospitalizations. The patients who were admitted with the primary reason of thyroid dysfunction were included using appropriate international classification of disease, ninth revision, clinical modification (ICD-9-CM) codes. We then identified new-onset arrhythmias using appropriate ICD-9-CM codes. We utilized the "present on admission" variable to exclude arrhythmias that were present on admission. Among the eligible patients with thyroid dysfunction, only 3% (n=12,111) developed a new-onset arrhythmia. Atrioventricular block (1.49%) is the most frequent followed by atrial fibrillation (0.92%), ventricular tachycardia (0.47%), atrial flutter (0.23%), supraventricular tachycardia (0.1%) and ventricular fibrillation (0.07%). Patients with new-onset arrhythmias were older (mean age 76.7±12.5 years), more predominantly white (n=9008, 74.4%), higher females (n= 7632, 63%), and had a higher frequency of comorbidities. In-hospital mortality occurred in 827 (6.8%) patients with new-onset arrhythmias and 8632 (2.2%) patients without new-onset arrhythmias (P-value <0.001). The medical length of stay and cost of hospitalization was also higher in these patients. Thyroid dysfunction is not associated with significantly higher rates of new-onset arrhythmias while inpatient. However, when developed, these arrhythmias are associated with higher mortality and resource utilization. The patients admitted to the hospital should have thyroid function checked when found to have an arrhythmia. [ABSTRACT FROM AUTHOR]

Background: We sought to describe the burden of arrhythmias and their impact on in‐hospital outcomes in transgender patients who underwent gender re‐assignment surgery. Methods: The study utilized data from the National Inpatient Sample from January 2012 to September 2015. Results: 16 555 adult transgender patients were included in this study. A total of 610 adults developed arrhythmia out of which atrial fibrillation (N = 475, 2.87%) was the most frequent arrhythmia. In‐hospital mortality increased substantially with arrhythmias. Conclusions: New‐onset arrythmias, while infrequent in the inpatient setting is associated with significantly higher in‐hospital mortality and resource utilization. [ABSTRACT FROM AUTHOR]

Opioid overdose-related hospitalizations continue to rise in the United States. These hospitalizations are frequently associated with arrhythmia which can increase in-hospital mortality and resource utilization. We describe temporal trends in the hospitalizations for opioid overdose, associated arrhythmias, and their impact on in-hospital mortality, length of stay and cost of hospitalizations. The purpose of this study was to identify incidence of arrhythmia and their impact on in-hospital outcomes with opioid overdose hospitalizations. The study utilized data from the National Inpatient Sample from January 2005 to September 2015. Previously employed International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis codes were utilized to identify opioid overdose and associated arrhythmias. The analysis was performed using SAS (SAS Institute Inc., Cary, NC). Temporal trends were measured using Jonckheere-Terpstra Trend test. A total of 430,460 adult hospitalizations with opioid overdose were included in this study. Atrial fibrillation (N = 17,695, 4.1%) was the most frequent arrhythmia associated with opioid overdose, the trend of which increased significantly during the study period. All-cause in-hospital mortality increased substantially with arrhythmias, highest with ventricular fibrillation and ventricular tachycardia. The incidence of arrhythmias was associated with longer length of stay and higher cost of hospitalizations as well. Incidence of new-onset arrhythmia with opioid overdose lead to higher in-hospital mortality which can further increase the length of hospitalization and cost of care. • Arrhythmias associated with opioid overdose are increasing significantly. • Atrial fibrillation is the most common arrhythmias associated with opioid overdose. • These arrhythmias are associated with higher in-hospital mortality. • These leads to higher resource utilization with longer stay and higher cost. [ABSTRACT FROM AUTHOR]