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Arrhythmias development determined by structural alterations of the heart, renin-angiotensin system activity and genetic factors.The purpose of our study was to evaluate angiotensin 2 receptor type 1 (AT2P1) gene polymorphism effect on development of arrhythmias in hypertensive patients.Were examined 125 patients with arterial hypertension (AH) 1-3 grade complicated by HF I-II NYHA functional class. The mean age of patients - 52.2 (6.8) years. Patients with acute myocardial infarction in history, diabetes mellitus and autoimmune diseases were excluded from the study. In all patients was performed ECG in 12 standard leads, Holter ECG monitoring, EchoCG (ASE/EAE recommendations 2005). HF NYHA functional class was determined by using the 6MWT. Extrasystoles types were determined by Lown B. classification. Genotyping of AT2P1 gene was performed by polymerase chain reaction analysis of DNA restriction fragments length.Statistical significance was defined at the level of methods for p<0,05.As it can be seen from Table 1 the presence of C allele in genotype of AT2P1 gene accompanied by a statistically significant increase of the frequency of high grade ventricular extrasystoles in comparison with homozygous AA type: 5 patients (7%) with AA and 9 patients (20%) with AC: Chi2 =3.8, p= 0.048, RR= 2.8 (95%CI 1.06 - 7.9).Thus, results of our study indicates role of C allele in genotype of AT2P1 gene in development of high grade ventricular extrasystoles in hypertensive patients.AT2P1 gene polymorphism & arrhythmiasGenotypeArrhythmia typeAA n=71AC n=44CC n=10n (%)n (%)n (%)all SVPB45 (63%)33 (75%)7 (70%) Rare SVPB33 (46%)19 (43%)4 (40%) Frequent SVPB12 (17%)14 (32%)3 (30%)Paroxysmal AF7 (10%)5 (11%)-Supraventricular tachycardia4 (6%)3 (5%)1 (10%)all ventricular extrasystoles26 (37%)21 (48%)6 (60%) Rare ventricular extrasystoles19 (27%)15 (34%)4 (40%) Frequent ventricular extrasystoles7 (10%)6 (14%)2 (20%) Ventricular extrasystole 3-4 grade5 (7%)9 (20%)2 (20%)SVPB - supraventricular premature beats, AF - atrial fibrillation [ABSTRACT FROM AUTHOR]