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Your search keyword '"R. N. Hauer"' showing total 5 results
Start Over Author "R. N. Hauer" Topic arrhythmias, cardiac
5 results on '"R. N. Hauer"'

1. Indications for implantable cardioverter defibrillator (ICD) therapy

Author

R N, Hauer, E, Aliot, M, Block, A, Capucci, B, Lüderitz, M, Santini, and P E, Vardas

Subjects
Cardiomyopathy, Dilated, Europe, Death, Sudden, Cardiac, Cardiac Pacing, Artificial, Heart Valve Diseases, Humans, Arrhythmias, Cardiac, Coronary Artery Disease, Cardiomyopathy, Hypertrophic, Arrhythmogenic Right Ventricular Dysplasia, Defibrillators, Implantable, Randomized Controlled Trials as Topic
Published
2001

2. Genetic and molecular basis of cardiac arrhythmias; impact on clinical management. Study group on molecular basis of arrhythmias of the working group on arrhythmias of the european society of cardiology

Author

S G, Priori, J, Barhanin, R N, Hauer, W, Haverkamp, H J, Jongsma, A G, Kleber, W J, McKenna, D M, Roden, Y, Rudy, K, Schwartz, P J, Schwartz, J A, Towbin, and A, Wilde

Subjects
Electrocardiography, Phenotype, Mutation, Chromosomes, Human, Humans, Arrhythmias, Cardiac, DNA, Molecular Biology, Ion Channels
Published
1999

3. Valsalva termination of ventricular tachycardia in myocardial infarction

Author

N, de Jonge, H W, Meijburg, R N, Hauer, and E O, Robles de Medina

Subjects
Male, Valsalva Maneuver, Heart Ventricles, Myocardial Infarction, Humans, Arrhythmias, Cardiac, Aged
Abstract

A 66-yr-old patient with recurrent monomorphic ventricular tachycardias subsequent to a previous myocardial infarction is reported. The tachycardia could repeatedly be terminated by the Valsalva manoeuvre. Procainamide, infused shortly before, possibly had an additional effect. As far as we know, this is the first report of ventricular tachycardias, as a result of an old myocardial infarction, that could be terminated by the Valsalva manoeuvre.

Published
1990

4. Amiodarone and desethylamiodarone concentrations in plasma and tissues of surgically treated patients on long-term oral amiodarone treatment

Author

T A, Plomp, R N, Hauer, and E O, Robles de Medina

Subjects
Adult, Male, Adipose Tissue, Administration, Oral, Amiodarone, Humans, Arrhythmias, Cardiac, Tissue Distribution, Middle Aged, Chromatography, High Pressure Liquid, Aged
Abstract

The tissue disposition of amiodarone and its metabolite desethylamiodarone was studied in 12 surgical patients with various types of arrhythmias after chronic oral treatment with amiodarone. Amiodarone and desethylamiodarone concentrations in plasma and tissues were determined using a simple and sensitive high performance liquid chromatographic method. The mean plasma level of amiodarone and desethylamiodarone was found to increase from 0.55 microgram/ml to 1.40 microgram/ml and 0.68 microgram/ml to 1.80 microgram/ml for the respective components following the increase of the daily oral dose from 200 mg to 600 mg of amiodarone and indicates a linear relationship between plasma concentrations and dose. The mean levels of both drugs in different parts of the heart varied for amiodarone from 15 to 48 micrograms/g and for desethylamiodarone from 48 to 71 micrograms/g, with the highest values present in the epicardially resected ventricular myocardium. The mean cardiac tissue/plasma ratios ranged for amiodarone from 12 to 35 and for desethylamiodarone from 35 to 61 and show an extensive tissue uptake in the different parts of the heart for both drugs, with the metabolite accumulation 2 to 5 times higher than the parent compound. Relatively low levels, ranging for amiodarone from 2 to 15 micrograms/g and for desethylamiodarone from 5 to 25 micrograms/g, were observed in skeletal muscle, epidermis, skin and femoral artery. By far the largest content of the drugs was found in adipose tissue with mean concentrations of 207 +/- 98 micrograms/g and 82 +/- 43 g/g respectively for the parent compound and its metabolite, which suggests that fat constitutes the main depot of the drugs.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1990

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