1. Diffuse optical characterization of an exercising patient group with peripheral artery disease.
- Author
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Mesquita, Rickson C., Putt, Mary, Chandra, Malavika, Guoqiang Yu, Xiaoman Xing, Sung Wan Han, Lech, Gwen, Yu Shang, Durduran, Turgut, Chao Zhou, Yodh, Arjun G., and Mohler III, Emile R.
- Subjects
ARTERIAL diseases ,NEAR infrared spectroscopy ,MUSCLE blood-vessels ,BLOOD flow ,CARDIOVASCULAR diseases ,HEMODYNAMICS - Abstract
Peripheral artery disease (PAD) is a common condition with high morbidity. While measurement of tissue oxygen saturation (S
t O2 ) has been demonstrated, this is the first study to assess both St O2 and relative blood flow (rBF) in the extremities of PAD patients. Diffuse optics is employed to measure hemodynamic response to treadmill and pedal exercises in 31 healthy controls and 26 patients. For St O2 , mild and moderate/severe PAD groups show pronounced differences compared with controls. Pre-exercise mean St O2 is lower in PAD groups by 9.3%to 10.6% compared with means of 63.5% to 66.2% in controls. For pedal, relative rate of return of St O2 to baseline is more rapid in controls (p < 0.05). Patterns of rBF also differ among groups. After both exercises, rBF tend to occur at depressed levels among severe PAD patients compared with healthy (p < 0.05); post-treadmill, rBF tend to occur at elevated levels among healthy compared with severe PAD patients (p < 0.05). Additionally, relative rate of return to baseline St O2 is more rapid among subjects with reduced levels of depression in rBF (p = 0.041), even after adjustment for ankle brachial index. This suggests a physiologic connection between rBF and oxygenation that can be measured using diffuse optics, and potentially employed as an evaluative tool in further studies. [ABSTRACT FROM AUTHOR]- Published
- 2013
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