1. Carotid arterial mechanics as useful biomarker of extracellular matrix turnover and preserved ejection fraction heart failure
- Author
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Wen-Hung Huang, Kevin Ning Zhou, Hung-I Yeh, Chih-Hsuan Yen, Ta-Chuan Hung, Jui-Peng Tsai, Shun-Chuan Chang, Shih-Chieh Chien, Chung-Lieh Hung, Kuo-Tzu Sung, Chun-Ho Yun, Cheng-Huang Su, and Ping-Ying Lee
- Subjects
Male ,medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Carotid circumferential strain ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Original Research Articles ,Internal medicine ,medicine ,Humans ,Original Research Article ,030212 general & internal medicine ,Aged ,Heart Failure ,Ejection fraction ,business.industry ,Carotid arterial deformation ,Stroke Volume ,Middle Aged ,medicine.disease ,Arterial stiffness ,Confidence interval ,Pathophysiology ,Extracellular Matrix ,Carotid Arteries ,Heart failure with preserved ejection fraction ,lcsh:RC666-701 ,Heart failure ,Hypertension ,Cardiology ,Matrix Metalloproteinase 2 ,Biomarker (medicine) ,Female ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers - Abstract
Aims We aimed to investigate the functional alterations, diagnostic utilization, and prognostic implication of carotid arterial deformations in subjects with cardiovascular risk factors and heart failure (HF) with preserved ejection fraction (HFpEF). Methods and results Among 251 prospectively participants (mean age 66.0 ± 9.8 years, 65.7% female) in a single centre between December 2011 and September 2014, carotid artery deformations including circumferential strain (CCS)/strain rate and radial strain were analysed by two‐dimensional speckle tracking. We further related these carotid artery deformation indices to HF biomarkers and cardiac structure and function by echocardiography and explored their prognostic values. Significant reductions of CCS, circumferential strain rate, and circumferential radial strain were observed across control (n = 52), high risk (n = 147), and HFpEF (n = 52) (trend P ≤ 0.001). Aging, hypertension, HFpEF, and higher pulse rate showed independent associations with reduced CCS by stepwise multivariate regressions (all P
- Published
- 2020