1. Monocyte production of C1q potentiates CD8 (+) T cell effector function following respiratory viral infection
- Author
-
Eddens, Taylor, Parks, Olivia B., Lou, Dequan, Fan, Li, Sojati, Jorna, Ramsey, Manda Jo, Schmitt, Lori, Salgado, Claudia M., Reyes-Mugica, Miguel, Oury, Tim D., Byersdorfer, Craig, Chen, Kong, and Williams, John V.
- Subjects
Article - Abstract
Respiratory viral infections remain a leading cause of morbidity and mortality. Using a murine model of human metapneumovirus (HMPV), we identified recruitment of a C1q-producing inflammatory monocyte population concomitant with viral clearance by adaptive immune cells. Genetic ablation of C1q led to reduced CD8 (+) T cell function. Production of C1q by a myeloid lineage was sufficient to enhance CD8 (+) T cell function. Activated and dividing CD8 (+) T cells expressed a putative C1q receptor, gC1qR. Perturbation of gC1qR signaling led to altered CD8 (+) T cell IFN-γ production and metabolic capacity. Autopsy specimens from fatal respiratory viral infections in children demonstrated diffuse production of C1q by an interstitial population. Humans with severe COVID-19 infection also demonstrated upregulation of gC1qR on activated and rapidly dividing CD8 (+) T cells. Collectively, these studies implicate C1q production from monocytes as a critical regulator of CD8 (+) T cell function following respiratory viral infection.
- Published
- 2023