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1. Analysis of the Trichuris suis excretory/secretory proteins as a function of life cycle stage and their immunomodulatory properties

Author

Rajesh M. Valanparambil, Armando Jardim, Elizabeth Siciliani, Dante S. Zarlenga, Timothy G. Geary, Louis-Philippe Leroux, Maritza Jaramillo, Mifong Tam, Dolores E. Hill, Makedonka Mitreva, Mohamad Nasr, Joel V. Weinstock, Joseph F. Urban, Mary M. Stevenson, Bruce A. Rosa, Institut Armand Frappier (INRS-IAF), Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS), Centre for Host-Parasite Interaction [Montreal] (CHPI), Institute of Parasitology [Sainte-Anne-de-Bellevue], McGill University = Université McGill [Montréal, Canada], The McDonnell Genome Institute (MGI), Washington University in Saint Louis (WUSTL), USDA Agricultural Research Service [Maricopa, AZ] (USDA), United States Department of Agriculture (USDA), Tufts Medical Center [Boston], Research was supported in part from a grant from Natural Sciences and Engineering Research Council of Canada Discovery Grant #238249, (A.J.) and Canadian Institutes of Health Research grants to (A.J., M.M.S.). The work at Washington University was supported by NIH grants AI081803 and GM097435 to M.M. The work at the USDA was supported by ARS Research Project 1265-32000-094-00D., and We wish to acknowledge Daniel Defoy at the Proteomics Platform of the Quebec Genomics Center part of the Centre de Recherche du Centre Hospitalier de l’Université Laval (CRCHUL) (Quebec City, QC, Canada) for performing the LC-MS/MS analyses.

Subjects
0301 basic medicine, Swine, medicine.medical_treatment, T cell, lcsh:Medicine, Nitric Oxide, T-Lymphocytes, Regulatory, Article, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Animals, Secretion, IL-2 receptor, lcsh:Science, Life Cycle Stages, Multidisciplinary, Arginase, biology, Chemistry, Macrophages, lcsh:R, Trichuris suis, FOXP3, Dendritic Cells, Helminth Proteins, biology.organism_classification, Cell biology, Trichuris, 030104 developmental biology, Cytokine, medicine.anatomical_structure, Cytokines, [SDV.IMM]Life Sciences [q-bio]/Immunology, Tumor necrosis factor alpha, lcsh:Q, 030215 immunology
Abstract

Parasitic worms have a remarkable ability to modulate host immune responses through several mechanisms including excreted/secreted proteins (ESP), yet the exact nature of these proteins and their targets often remains elusive. Here, we performed mass spectrometry analyses of ESP (TsESP) from larval and adult stages of the pig whipworm Trichuris suis (Ts) and identified ~350 proteins. Transcriptomic analyses revealed large subsets of differentially expressed genes in the various life cycle stages of the parasite. Exposure of bone marrow-derived macrophages and dendritic cells to TsESP markedly diminished secretion of the pro-inflammatory cytokines TNFα and IL-12p70. Conversely, TsESP exposure strongly induced release of the anti-inflammatory cytokine IL-10, and also induced high levels of nitric oxide (NO) and upregulated arginase activity in macrophages. Interestingly, TsESP failed to directly induce CD4+ CD25+ FoxP3+ regulatory T cells (Treg cells), while OVA-pulsed TsESP-treated dendritic cells suppressed antigen-specific OT-II CD4+ T cell proliferation. Fractionation of TsESP identified a subset of proteins that promoted anti-inflammatory functions, an activity that was recapitulated using recombinant T. suis triosephosphate isomerase (TPI) and nucleoside diphosphate kinase (NDK). Our study helps illuminate the intricate balance that is characteristic of parasite-host interactions at the immunological interface, and further establishes the principle that specific parasite-derived proteins can modulate immune cell functions.

Published
2018

2. New Sequencing technologies help revealing unexpected mutations in Autosomal Dominant Hypercholesterolemia

Author

Jean-Pierre Rabès, Mathilde Varret, Catherine Boileau, Marianne Abifadel, Eric Bruckert, Gina M. Peloso, Ali Ben-Djoudi-Ouadda, Josée Hamelin, Nabil G. Seidah, Youmna Ghaleb, Nathan O. Stitziel, Valérie Carreau, Petra El Khoury, Sandy Elbitar, Delia Susan-Resiga, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Saint-Joseph de Beyrouth (USJ), Université Paris Diderot - Paris 7 (UPD7), Université de Montréal (UdeM), Boston University [Boston] (BU), The McDonnell Genome Institute (MGI), Washington University in Saint Louis (WUSTL), Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Service de Nutrition [CHU Pitié-Salpétrière], Institut E3M [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Pierre et Marie Curie - Paris 6 (UPMC), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de nutrition [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
0301 basic medicine, Male, Heterozygote, Apolipoprotein B, lcsh:Medicine, 030204 cardiovascular system & hematology, medicine.disease_cause, Compound heterozygosity, Article, Hyperlipoproteinemia Type II, 03 medical and health sciences, Exon, 0302 clinical medicine, Chromosome Segregation, medicine, Humans, Family, lcsh:Science, Gene, Exome, Exome sequencing, Apolipoproteins B, Genetics, Mutation, Multidisciplinary, biology, lcsh:R, nutritional and metabolic diseases, High-Throughput Nucleotide Sequencing, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, 3. Good health, Pedigree, 030104 developmental biology, HEK293 Cells, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, LDL receptor, biology.protein, lcsh:Q, lipids (amino acids, peptides, and proteins), Female, Proprotein Convertase 9
Abstract

Autosomal dominant hypercholesterolemia (ADH) is characterized by elevated LDL-C levels leading to coronary heart disease. Four genes are implicated in ADH: LDLR, APOB, PCSK9 and APOE. Our aim was to identify new mutations in known genes, or in new genes implicated in ADH. Thirteen French families with ADH were recruited and studied by exome sequencing after exclusion, in their probands, of mutations in the LDLR, PCSK9 and APOE genes and fragments of exons 26 and 29 of APOB gene. We identified in one family a p.Arg50Gln mutation in the APOB gene, which occurs in a region not usually associated with ADH. Segregation and in-silico analysis suggested that this mutation is disease causing in the family. We identified in another family with the p.Ala3396Thr mutation of APOB, one patient with a severe phenotype carrying also a mutation in PCSK9: p.Arg96Cys. This is the first compound heterozygote reported with a mutation in APOB and PCSK9. Functional studies proved that the p.Arg96Cys mutation leads to increased LDL receptor degradation. This work shows that Next-Generation Sequencing (exome, genome or targeted sequencing) are powerful tools to find new mutations and identify compound heterozygotes, which will lead to better diagnosis and treatment of ADH.

Published
2018

3. Whole-genome analyses resolve early branches in the tree of life of modern birds

Author

Bhanu Rekepalli, Jaime Huerta-Cepas, David Haussler, Beth Shapiro, Frank E. Rheindt, Bo Li, Per Alström, Oliver A. Ryder, Salvador Capella-Gutierrez, Jianwen Li, José Alfredo Samaniego, Binghang Liu, Paula F. Campos, David P. Mindell, Xiangjiang Zhan, An Pas, Yinhua Huang, Liang Liu, Scott V. Edwards, Dave Burt, David A. Ray, Andrew Dixon, Hui Li, Toni Gabaldón, Bastien Boussau, Cai Li, Hans Ellegren, Carsten Rahbek, Shengbin Li, Michael J. Braun, Peter Houde, Peter V. Lovell, Alexandros Stamatakis, Claudia C. Weber, Yong Zhang, Jian Wang, Thomas Sicheritz-Pontén, Volodymyr Zavidovych, Alexander Suh, Xiong Yinqi, Maria Paula Cruz Schneider, Stephen J. O'Brien, Ganesh Ganapathy, Shamsuzzoha Bayzid, Huanming Yang, Guojie Zhang, Alonzo Alfaro-Núñez, Claudio V. Mello, Michael Bunce, Amy C. Driskell, Francisco Prosdocimi, Zijun Xiong, Joel Cracraft, Long Zhou, Mikkel H. Schierup, Brant C. Faircloth, Gary R. Graves, F. Keith Barker, Jon Fjeldså, Benoit Nabholz, Bent E. K. Lindow, Frederick H. Sheldon, Robb T. Brumfield, Nitish Narula, Bent O. Petersen, Kasper Munch, Klaus-Peter Koepfli, Rute R. da Fonseca, Thomas L. Bailey, Kui Wu, Quiemei Zheng, Tandy Warnow, John E. McCormack, Elizabeth P. Derryberry, Linnéa Smeds, Simon Y. W. Ho, Polina L. Perelman, Siavash Mirarab, Qi Zhou, Michael William Bruford, Knud A. Jønsson, M. Thomas P. Gilbert, Ning Li, Richard E. Green, Edward L. Braun, R. Paul Scofield, Wesley C. Warren, Zhenyu Li, Fang Zhang Zhang, Warren E. Johnson, Morgan Wirthlin, Jason T. Howard, Travis C. Glenn, Ludovic Orlando, Mads F. Bertelsen, David M. Lambert, Andre J. Aberer, Erich D. Jarvis, Sankar Subramanian, Amhed Missael Vargas Velazquez, Yongli Zeng, Eske Willerslev, Jin Xiao, Shiping Liu, Wang Jun, Howard Hughes Medical Institute (HHMI), Duke University Medical Center, University of Texas at Austin [Austin], Heidelberg Institute for Theoretical Studies (HITS ), Beijing Genomics Institute [Shenzhen] (BGI), Xi'an Jiaotong University (Xjtu), Natural History Museum of Denmark, Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), New Mexico State University, The University of Sydney, University of California, Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Evolutionary Biology Centre (EBC), Uppsala University, Okinawa Institute of Science and Technology Graduate University, University of Georgia [USA], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Griffith University [Brisbane], Centre for Genomic Regulation [Barcelona] (CRG), Universitat Pompeu Fabra [Barcelona] (UPF)-Centro Nacional de Analisis Genomico [Barcelona] (CNAG), Institució Catalana de Recerca i Estudis Avançats (ICREA), Joint Institute for Computational Sciences [Knoxville] (JICS), The University of Tennessee [Knoxville], Oak Ridge National Laboratory [Oak Ridge] (ORNL), UT-Battelle, LLC, Aarhus University [Aarhus], The McDonnell Genome Institute (MGI), Washington University in Saint Louis (WUSTL), Department of Biochemistry, Molecular Biology, Entomology and Plant Pathology [Mstate, USA] (BCH-EPP), Mississippi State University [Mississippi], Department of Biological Sciences [Lubbock], Texas Tech University [Lubbock] (TTU), Department of Ecology and Evolutionary Biology [Santa Cruz], University of California [Santa Cruz] (UCSC), University of California-University of California, School of Biosciences [Cardiff], Cardiff University, Kunming Institute of Zoology, Chinese Academy of Sciences [Beijing] (CAS), International Wildlife Consultants Ltd, China Agricultural University (CAU), Tulane University, Louisiana State University (LSU), Copenhagen Zoo, Oregon Health and Science University [Portland] (OHSU), Federal University of Para - Universidade Federal do Para [Belem - Brésil], Technical University of Denmark [Lyngby] (DTU), Breeding Centre for Endangered Arabian Wildlife, Dubai Hospital, Canterbury Museum, Curtin University [Perth], Planning and Transport Research Centre (PATREC), Department of Integrative Biology [Berkeley] (IB), University of California [Berkeley], National Cancer Institute Frederick, Novosibirsk State University (NSU), Smithsonian Institution, Department of Biological Sciences [Singapore], National University of Singapore (NUS), Bell Museum of Natural History, University of Minnesota [Twin Cities] (UMN), University of Minnesota System-University of Minnesota System, Department of Life Sciences, Imperial College London, Smithsonian Conservation Biology Institute, Theodosius Dobzhansky Center for Genome Bioinformatics, St Petersburg State University (SPbU), Nova Southeastern University (NSU), Center for Biomolecular Science and Engineering, San Diego Zoo Global Institute for Conservation Research, Occidental College, The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Key Laboratory of Zoological Systematics and Evolution, Chinese Academy of Agricultural Sciences (CAAS), Swedish Species Information Centre, Swedish University of Agricultural Sciences (SLU), Department of Organismic and Evolutionary Biology [Cambridge] (OEB), Harvard University [Cambridge], Institute of Theoretical Informatics, Karlsruhe Institute of Technology (KIT), Department of Biochemistry and Biophysics [San Francisco], American Museum of Natural History (AMNH), University of Florida [Gainesville] (UF), University of Illinois at Urbana-Champaign [Urbana], University of Illinois System, University of Copenhagen = Københavns Universitet (KU), King Abdulaziz University, Macau University of Science and Technology (MUST), The University of Hong Kong (HKU), University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), University of California (UC), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), University of California [Santa Cruz] (UC Santa Cruz), University of California (UC)-University of California (UC), Kunming Institute of Zoology (KIZ), Federal University of Para - Universidade Federal do Pará - UFPA [Belém, Brazil] (UFPA), Danmarks Tekniske Universitet = Technical University of Denmark (DTU), University of California [Berkeley] (UC Berkeley), Biotechnology and Biological Sciences Research Council (BBSRC), Harvard University, and University of Copenhagen = Københavns Universitet (UCPH)

Subjects
Palaeognathae, MESH: Sequence Analysis, DNA, Genetic Speciation, MESH: Introns, Zoology, MESH: Biological Evolution, MESH: Base Sequence, Article, Coalescent theory, Avian Proteins, Birds, MESH: INDEL Mutation, INDEL Mutation, MESH: Avian Proteins, Animals, MESH: Animals, MESH: Genome, MESH: Phylogeny, Clade, Phylogeny, MESH: Genetic Speciation, Genome, Multidisciplinary, Columbea, Base Sequence, biology, Phylogenetic tree, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Sequence Analysis, DNA, Passerea, biology.organism_classification, Biological Evolution, Introns, MESH: Genes, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, Genes, MESH: DNA Transposable Elements, Neognathae, MESH: Birds, DNA Transposable Elements, Neoaves
Abstract

International audience; To better determine the history of modern birds, we performed a genome-scale phylogenetic analysis of 48 species representing all orders of Neoaves using phylogenomic methods created to handle genome-scale data. We recovered a highly resolved tree that confirms previously controversial sister or close relationships. We identified the first divergence in Neoaves, two groups we named Passerea and Columbea, representing independent lineages of diverse and convergently evolved land and water bird species. Among Passerea, we infer the common ancestor of core landbirds to have been an apex predator and confirm independent gains of vocal learning. Among Columbea, we identify pigeons and flamingoes as belonging to sister clades. Even with whole genomes, some of the earliest branches in Neoaves proved challenging to resolve, which was best explained by massive protein-coding sequence convergence and high levels of incomplete lineage sorting that occurred during a rapid radiation after the Cretaceous-Paleogene mass extinction event about 66 million years ago.

Published
2014

4. Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Author

Gerald M. Mkoji, Ittiprasert Wannaporn, Xiao-Jun Wu, Julia B. Carleton, Gloria I. Giraldo-Calderón, Matty Knight, Catherine S. Jones, Anthony T. Papenfuss, Elio Hideo Baba, Brian J. Raney, Richard M. Cripps, Christine Coustau, Martin T. Swain, René Feyereisen, Judith E. Humphries, Nithya Raghavan, Kathryn M. Ryan, Céline Cosseau, Karl F. Hoffmann, Michael S. Blouin, Edwin J. Routledge, TyAnna L. Lovato, Min Zhao, Olga Baron, Fabiano Sviatopolk-Mirsky Pais, Mikkel Christensens, Sandra W. Clifton, Leonid L. Moroz, Maria G. Castillo, Damian L. Trujillo, Donald P. McManus, Emanuela V. Volpi, Liana K. Jannotti-Passos, Scott P Lawton, Joanna M. Bridger, Yesid Cuesta-Astroz, Eric S. Loker, David Duval, Fernanda Ludolf, Bronwyn Rotgans, Mónica Medina, Di Liang, Benjamin Gourbal, Izinara C Rosse, Catrina Fronick, Sarah K. Buddenborg, Roberta Lima Caldeira, Umar Niazi, Aurélie Kapusta, Christoph Grunau, Scott F. Cummins, Katherine M. Buckley, Milind Misra, Matheus de Souza Gomes, LaDeana W. Hillier, Iain W. Chalmers, Guillaume Mitta, Scott J. Emrich, Kathrin K. Geyer, Wander de Jesus Jeremias, Larissa L. S. Scholte, Laurence Rodrigues do Amaral, Juliana G Assis, Jacob A. Tennessen, Emmanuel A. Pila, Patrick C. Hanington, Andrew M. Shedlock, Wesley C. Warren, Chris Botka, Sandra Grossi Gava, Coen M. Adema, Janeth J. Pena, Satwant Kaur, Chad Tomlinson, Richard Galinier, Michelle A. Gordy, Bishoy Kamel, Guilherme Oliveira, Anne E. Lockyer, Jonathan P. Rast, Andrea B. Kohn, Daniel Lawson, Richard K. Wilson, Patrick Minx, Bryony C. Bonning, Peter C. FitzGerald, Christopher J. Bayne, Omar dos Santos Carvalho, Monica Munoz-Torres, Tianfang Wang, David Rollinson, Vince Magrini, Kyle K. Biggar, Titouan Quelais, Leslie R. Noble, Utibe Bickham-Wright, Francislon Silva de Oliveira, Cédric Feschotte, Daniel J. Jackson, Joris M. Koene, Michael J. Montague, Anthony J. Walker, Lucinda Fulton, Daniel S.T. Hughes, Susan Jobling, Rob Peace, Halime D. Arican-Goktas, Nathalie Dinguirard, Timothy P. Yoshino, Mohammed Yusuf, Cesar E. Montelongo, Michael E. Geusz, Sijun Liu, Si-Ming Zhang, Kenneth B. Storey, Leon di Stephano, Yanin Limpanont, Center for Evolutionary and theoretical Immunology, Biology, The University of New Mexico [Albuquerque], The McDonnell Genome Institute (MGI), Washington University in St Louis, INSTITUTE OF BIOLOGICAL AND ENVIRONMENTAL SCIENCES, University of Aberdeen, Department of Microbiology, Immunology & Tropical Medicine and Research Center for Neglected Diseases of Poverty, George Washington University (GW), Division of Science & Mathematics, University of the District of Columbia, Fiocruz Minas - René Rachou Research Center / Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), sans affiliation, Biology Department, Medical University of South Carolina [Charleston] (MUSC), Laboratory of Bioinformatics and Molecular Analysis, Federal University of Uberlândia [Uberlândia] (UFU), Department of Life Sciences, College of Health and Life Sciences, Brunel University London [Uxbridge], Institut Sophia Agrobiotech [Sophia Antipolis] (ISA), Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Department of Integrative Biology, Oregon State University (OSU), Department of Pathobiological Sciences, University of Wisconsin-Madison, Institute of Biochemisty and Department of Biology, Carleton University, Iowa State University (ISU), Department of Information Technology, Harvard Medical School, Harvard Medical School [Boston] (HMS), Sunnybrook Health Sciences Centre, Department of Immunology, University of Toronto, Department of Human Genetics [Salt Lake City], University of Utah, Biology, New Mexico State University, New Mexico State University, Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, EMBL-EBI, Wellcome Genome Campus, Interactions Hôtes-Pathogènes-Environnements (IHPE), Université de Perpignan Via Domitia (UPVD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Faculty of Science, Health and Education, University of the Sunshine Coast, The Walter and Eliza Hall Institute for Medical Research (WEHI), Genomics and Bioinformatics Core Facility, University of Notre Dame [Indiana] (UND), Department of Plant and Environmental Sciences [Copenhagen], Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Genome Analysis Unit, National Cancer Institute, National Institutes of Health [Bethesda] (NIH), Biological Sciences, Bowling Green State University, Bowling Green State University, IBERS, Institute of Biological, Environmental and Rural Sciences, Biotechnology and Biological Sciences Research Council, Department of Public Health Sciences, University of Alberta, University of Alberta, Department of Biology, Lawrence University, Lawrence University, Courant Research Centre Geobiology, Georg-August University of Göttingen, Georg-August-University [Göttingen], Institute of Environment, Health & Societies, Environment and Health Theme, Brunel University London, Brunel University London, Department of Biology, Pennsylvania State University (Penn State), Penn State System-Penn State System, Faculteit der Aard- en Levenswetenschappen, Vrije Universiteit, Vrije Universiteit Amsterdam [Amsterdam] (VU), The Whitney Laboratory for Marine Bioscience, University of Florida, University of Florida [Gainesville], Molecular Parasitology Laboratory, Kingston University, Kingston University, Faculty of Science, Health, Education and Engineering (USC), Molecular Parasitology Unit, Queensland Institute of Medical Research, Penn State System, Kenya Medical Research Institute (KEMRI), Department of Neuroscience (DEPARTMENT OF NEUROSCIENCE), University of Pennsylvania [Philadelphia], Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Bioinformatics and Cancer Genomics lab Lorenzo and Pamela Galli, Melanoma Research Fellow Peter MacCallum Cancer Centre, Institute for Genomics and Bioinformatics [Irvine], University of California [Irvine] (UCI), University of California-University of California, Parasites and Vectors Division, London Centre for Neglected Tropical Disease Research, Natural History Museum, Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster [London] (UOW), Molecular Parasitology Laboratory, School of Life Sciences Pharmacy and Chemistry, Sequence characterization of the Biomphalaria glabrata genome was funded by NIH-NHGRI grant HG003079 to R.K.W., McDonnell Genome Institute, Washington University School of Medicine. Biomphalaria glabrata and Schistosoma mansoni were provided to some participating labs by the NIAID Schistosomiasis Resource Center (Biomedical Research Institute, Rockville, MD) through NIH-NIAID Contract HHSN272201000005I for distribution through BEI Resources. C.M.A. and E.S.L. acknowledge NIH grant P30GM110907 from the National Institute of General Medical Sciences (NIGMS). Publication costs were contributed equally by McDonnell Genome Institute, Washington University School of Medicine and the COBRE Center for Evolutionary and Theoretical Immunology (CETI) which is supported by NIH grant P30GM110907 from the National Institute of General Medical Sciences (NIGMS). E.S.L. acknowledges NIH/NIAID ROI AI101438. J.M.B., H.D.A.-G and M.K. acknowledge NIH-NIAID R01-AI0634808. M.Y. acknowledges UK BBSRC (BB/H022597/1). G.O. acknowledges support from FAPEMIG (RED-00014-14, PPM-00189-13) and CNPq (304138/2014-2, 309312/2012-4). R.L.C. acknowledges CNPq (503275/2011-5). T.P.Y. acknowledges NIH/NIAID RO1AI015503. K.F.H. and M.T.S. acknowledge BBSRC (BB/K005448/1). B.G. acknowledges ANR JCJC INVIMORY (ANR-13-JSV7-0009). S.E. acknowledges NIAID contract HHSN272201400029C. J.M.K. acknowledges the Research Council for Earth and Life Sciences (A.L.W., 819.01.007) and the Netherlands Organization for Scientific Research (NWO). R.M.C. acknowledges NIH GM061738 and support from the American Heart Association, Southwest Affiliate (14GRNT20490250). D.T. acknowledges NIH R25 GM075149. C.F. acknowledges NIH R01-GM077582. D.J.J. acknowledges D.F.G. JA2108/1-2. M.de S.G. acknowledges CNPq 479890/2013-7. K.M.B. and J.P.R. acknowledge NSERC 312221 and CIHR MOP74667. C.S.J., L.R.N., S.J., E.J.R., S.K. and A.E.L. acknowledge NC3R GO900802/1. K.K.B. and K.B.S. acknowledge NSERC 315051 and 6793, respectively. M.B. and C.J.B. acknowledge NIH RO1-AI109134. C.J.B. acknowledges NIH AI016137 and AI111201. B.R. acknowledges NHGRI 4U41HG002371. P.C.H., M.A.G. and E.A.P. acknowledge NSERC 418540. O.L.B. and Ch.C. acknowledge ANR-12-EMMA-0007-01. S.F.C. acknowledges Australian Research Council FT110100990., We thank S. Newfeld for discussion of actin evolution, N. El Sayed and H. Tettelin for discussion of HSP annotation and expression. We acknowledge access to the Metafer microscopy system at the I. Robinson Research Complex, Harwell, Rutherford Appleton Laboratory, Oxon, UK (BBSRC Professorial Fellowship, grant number BB/H022597/1)., Washington University in Saint Louis (WUSTL), The George Washington University (GW), Fiocruz Minas - René Rachou Research Center / Instituto René Rachou [Belo Horizonte, Brésil], Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Perpignan Via Domitia (UPVD), The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Florida [Gainesville] (UF), Animal Ecology, and Adema, Coen M.

Subjects
0301 basic medicine, MESH: Sequence Analysis, DNA, Proteome, INTERMEDIATE HOST, MESH: Schistosoma mansoni, General Physics and Astronomy, Biomphalaria, Fresh Water, Snail, Genome informatics, Genome, Freshwater snail, Pheromones, MESH: Biomphalaria/parasitology, 0302 clinical medicine, Global health, ACTIN GENES, MESH: Animals, DNA sequencing, MESH: Stress, Physiological, MESH: Evolution, Molecular, MESH: Pheromones, Multidisciplinary, biology, INVERTEBRATE, schistosomiase, Schistosoma mansoni, Corrigenda, MESH: Gene Expression Regulation, 6. Clean water, Multidisciplinary Sciences, MESH: Proteome, MESH: DNA Transposable Elements, MESH: Fresh Water, Science & Technology - Other Topics, MESH: Animal Communication, Science, 030231 tropical medicine, MANSONI, Zoology, Schistosomiasis, MESH: Host-Parasite Interactions, General Biochemistry, Genetics and Molecular Biology, Article, Host-Parasite Interactions, Evolution, Molecular, 03 medical and health sciences, Stress, Physiological, biology.animal, MESH: Schistosomiasis mansoni/transmission, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], MD Multidisciplinary, parasitic diseases, medicine, Journal Article, Biomphalaria glabrata, Animals, MESH: Biomphalaria/genetics, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, BIOMPHALARIA-GLABRATA, Science & Technology, COMPLEXITY, escargot aquatique, MESH: Genome, fungi, RECOGNITION, General Chemistry, Sequence Analysis, DNA, biology.organism_classification, medicine.disease, bacterial infections and mycoses, EVOLUTION, Schistosomiasis mansoni, Animal Communication, [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, 030104 developmental biology, Gene Expression Regulation, MESH: Biomphalaria/immunology, INNATE IMMUNITY, DNA Transposable Elements, VERTEBRATE, biological
Abstract

Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis., Biomphalaria glabrata is a fresh water snail that acts as a host for trematode Schistosoma mansoni that causes intestinal infection in human. This work describes the genome and transcriptome analyses from 12 different tissues of B glabrata, and identify genes for snail behavior and evolution.

Published
2017

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