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Photodynamic therapy (PDT) offers several advantages for treating cancers, but its efficacy is highly dependent on light delivery to activate a photosensitizer. Advances in wireless technologies enable remote delivery of light to tumors, but suffer from key limitations, including low levels of tissue penetration and photosensitizer activation. Here, we introduce DeepLabCut (DLC)-informed low-power wireless telemetry with an integrated thermal/light simulation platform that overcomes the above constraints. The simulator produces an optimized combination of wavelengths and light sources, and DLC-assisted wireless telemetry uses the parameters from the simulator to enable adequate illumination of tumors through high-throughput (<20 mice) and multi-wavelength operation. Together, they establish a range of guidelines for effective PDT regimen design. In vivo Hypericin and Foscan mediated PDT, using cancer xenograft models, demonstrates substantial suppression of tumor growth, warranting further investigation in research and/or clinical settings. The efficacy of photodynamic therapy is highly dependent on light delivery to activate a photosensitizer. Here the authors report AI-enabled, implantable, multichannel wireless telemetry for photodynamic therapy to enable uniform delivery of multi-wavelength light to tumors. [ABSTRACT FROM AUTHOR]

General surgical procedures are subject to low-light conditions or a narrow angle of view, and such limitations in light limit visibility and complicate the given surgical procedure. Conventional lighted surgical tools rely on an external light source, which may be oriented into a cavity or mounted on a surgical instrument such as retractor, endoscopes, or suction tubes. However, such conventional lighted instruments do not provide adequate lighting during various surgical procedures. Here, we present a soft, miniaturized magnetic-enabled wireless surgical lighting patty. Specifically, the proposed surgical lighting patty that can be temporarily implanted into a cavity or surgical corridor provides lighting to the surgical subject and manages fluids in a surgical field. The surgical lighting patty is a multilayer patty, two outer layers of the lighted surgical patty and the center lighted layer. A reed switch in the central layer can activate the power supply in response to a magnet to emit the light from the light source. The result allows a dramatically simplified wireless operation. Moreover, it can provide various wavelengths of light to a surgical field for purposes such as illuminating the surgeon's field of vision, exciting dyes, and sterilizing surgical fields. [ABSTRACT FROM AUTHOR]