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Clinical reasoning is at the heart of physicians' competence, as it allows them to make diagnoses. However, diagnostic errors are common, due to the existence of reasoning biases. Artificial intelligence is undergoing unprecedented development in this context. It is increasingly seen as a solution to improve the diagnostic performance of physicians, or even to perform this task for them, in a totally autonomous and more efficient way. In order to understand the challenges associated with the development of artificial intelligence, it is important to understand how the machine works to make diagnoses, what are the similarities and differences with the physician's diagnostic reasoning, and what are the consequences for medical training and practice., (Copyright © 2020 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.)

Competing Interests: Competing interests: None declared.

Objective: More than half a million surgeries are performed every day worldwide, which makes surgery one of the most important component of global health care. In this context, the objective of this paper is to introduce a new method for the prediction of the possible next task that a surgeon is going to perform during surgery., Material and Method: We formulate the problem as finding the optimal registration of a partial sequence to a complete reference sequence of surgical activities. We propose an efficient algorithm to find the optimal partial alignment and a prediction system using maximum a posteriori probability estimation and filtering. We also introduce a weighting scheme allowing to improve the predictions by taking into account the relative similarity between the current surgery and a set of pre-recorded surgeries., Results: Our method is evaluated on two types of neurosurgical procedures: lumbar disc herniation removal and anterior cervical discectomy. Results show that our method outperformed the state of the art by predicting the next task that the surgeon will perform with 95% accuracy., Conclusions: This work shows that, even from the low-level description of surgeries and without other sources of information, it is often possible to predict the next surgical task when the conditions are consistent with the previously recorded surgeries. We also showed that our method is able to assess when there is actually a large divergence between the predictions and decide that it is not reasonable to make a prediction., (Copyright © 2017 Elsevier B.V. All rights reserved.)

Le raisonnement clinique est au cœur de la compétence des médecins, car il permet en particulier de poser des diagnostics. Les erreurs diagnostiques sont toutefois fréquentes, en raison de l'existence de biais de raisonnement. L'intelligence artificielle connaît dans ce contexte un développement sans précédent. Elle est de plus en plus considérée comme une solution pour améliorer la performance diagnostique des médecins, voire pour réaliser cette tâche à leur place, de façon totalement autonome et plus efficiente. Afin d'appréhender les enjeux liés à l'essor de l'intelligence artificielle, il est important de comprendre comment fonctionne la machine pour diagnostiquer, quels sont les points communs et les différences avec le raisonnement diagnostique du médecin, et quelles sont les conséquences sur le plan de la formation et de la pratique médicales. Clinical reasoning is at the heart of physicians' competence, as it allows them to make diagnoses. However, diagnostic errors are common, due to the existence of reasoning biases. Artificial intelligence is undergoing unprecedented development in this context. It is increasingly seen as a solution to improve the diagnostic performance of physicians, or even to perform this task for them, in a totally autonomous and more efficient way. In order to understand the challenges associated with the development of artificial intelligence, it is important to understand how the machine works to make diagnoses, what are the similarities and differences with the physician's diagnostic reasoning, and what are the consequences for medical training and practice. [ABSTRACT FROM AUTHOR]

Recently, Artificial Intelligence namely Deep Learning methods have revolutionized a wide range of domains and applications. Besides, Digital Pathology has so far played a major role in the diagnosis and the prognosis of tumors. However, the characteristics of the Whole Slide Images namely the gigapixel size, high resolution and the shortage of richly labeled samples have hindered the efficiency of classical Machine Learning methods. That goes without saying that traditional methods are poor in generalization to different tasks and data contents. Regarding the success of Deep learning when dealing with Large Scale applications, we have resorted to the use of such models for histopathological image segmentation tasks. First, we review and compare the classical UNet and Att-UNet models for colon cancer WSI segmentation in a sparsely annotated data scenario. Then, we introduce novel enhanced models of the Att-UNet where different schemes are proposed for the skip connections and spatial attention gates positions in the network. In fact, spatial attention gates assist the training process and enable the model to avoid irrelevant feature learning. Alternating the presence of such modules namely in our Alter-AttUNet model adds robustness and ensures better image segmentation results. In order to cope with the lack of richly annotated data in our AiCOLO colon cancer dataset, we suggest the use of a multi-step training strategy that also deals with the WSI sparse annotations and unbalanced class issues. All proposed methods outperform state-of-the-art approaches but Alter-AttUNet generates the best compromise between accurate results and light network. The model achieves 95.88% accuracy with our sparse AiCOLO colon cancer datasets. Finally, to evaluate and validate our proposed architectures we resort to publicly available WSI data: the NCT-CRC-HE-100K, the CRC-5000 and the Warwick colon cancer histopathological dataset. Respective accuracies of 99.65%, 99.73% and 79.03% were reached. A comparison with state-of-art approaches is established to view and compare the key solutions for histopathological image segmentation. [ABSTRACT FROM AUTHOR]