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Health digital twins (HDTs) are virtual representations of real individuals that can be used to simulate human physiology, disease, and drug effects. HDTs can be used to improve drug discovery and development by providing a data-driven approach to inform target selection, drug delivery, and design of clinical trials. HDTs also offer new applications into precision therapies and clinical decision making. The deployment of HDTs at scale could bring a precision approach to public health monitoring and intervention. Next steps include challenges such as addressing socioeconomic barriers and ensuring the representativeness of the technology based on the training and validation data sets. Governance and regulation of HDT technology are still in the early stages. [ABSTRACT FROM AUTHOR]

Generative AI (artificial intelligence) refers to algorithms and models, such as OpenAI's ChatGPT, that can be prompted to generate various types of content. In this narrative review, we present a selection of representative examples of generative AI applications in medicine and healthcare. We then briefly discuss some associated issues, such as trust, veracity, clinical safety and reliability, privacy, copyrights, ownership, and opportunities, e.g., AI-driven conversational user interfaces for friendlier human-computer interaction. We conclude that generative AI will play an increasingly important role in medicine and healthcare as it further evolves and gets better tailored to the unique settings and requirements of the medical domain and as the laws, policies and regulatory frameworks surrounding its use start taking shape. [ABSTRACT FROM AUTHOR]