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Solid‐supported lipid bilayers (SLBs) are excellent platforms for studying the biophysical properties of cell membranes. Among the existing approaches used to form SLBs, vesicle fusion and rupture onto solid supports are most commonly employed owing to their straightforward procedure. The current understanding of the mechanisms behind this approach has greatly benefited from the use of surface‐sensitive techniques, especially quartz crystal microbalance with dissipation monitoring (QCM‐D) in combination with other analytical techniques, such as atomic force microscopy (AFM) or localized surface plasmon resonance (LSPR). Herein, an overview of the pathways of vesicle adsorption and rupture under various experimental conditions is provided. Examples including recent findings of how the variation of the properties of lipid vesicles (size, charge), aqueous buffer (pH, ionic strength, osmotic pressure), and solid support (surface energy) affect the pathway mechanism of adsorption and rupture are provided. Recent reports on poorly understood properties such as surface roughness and topography are provided, together with the need for further studies relevant to biomimetic and sensing purposes. [ABSTRACT FROM AUTHOR]

This article provides an overview of the formation of supported lipid bilayers, which are important in various applications such as biosensors. The authors discuss different experimental conditions that can affect the formation of these bilayers, including the size and charge of lipid vesicles, pH, ionic strength, osmotic pressure of the aqueous buffer, and surface energy and topography of the solid support. The article also includes information about the authors and their research interests in lipid membrane biophysics and surface functionalization. [Extracted from the article]