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2 results on '"Tousif MI"'

1. α-Glucosidase and lipoxygenase inhibitory derivatives of cryptosporioptide from the endophytic fungus Cryptosporiopsis sp.

Author

Tousif MI, Shazmeen N, Riaz N, Shafiq N, Khatoon T, Schulz B, Ashraf M, Shaukat A, Hussain H, Jabbar A, and Saleem M

Subjects
Algorithms, Inhibitory Concentration 50, Models, Molecular, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Polyketides chemistry, Viburnum microbiology, Ascomycota chemistry, Lipoxygenase drug effects, Polyketides isolation & purification, Polyketides pharmacology, alpha-Glucosidases drug effects
Abstract

Two new cryptosporioptide-derived polyketides cryptosporioptides A (2) and B (3) were isolated from the extract of endophytic fungus Cryptosporiopsis sp. associated with the shrub, Viburnum tinus. The structures of the isolates were determined through spectral analysis including 1D NMR ((1)H, (13)C) and 2D NMR (HSQC, HMBC, COSY) techniques, HR-FAB-MS and by comparison with the reported data of cryptosporioptide (1). The relative stereochemistry was assigned with the help of NOESY analysis, the molecular model, and comparison of the optical rotation values with the reference compound 1.

Published
2014
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2. Cryptosporioptide: a bioactive polyketide produced by an endophytic fungus Cryptosporiopsis sp.

Author

Saleem M, Tousif MI, Riaz N, Ahmed I, Schulz B, Ashraf M, Nasar R, Pescitelli G, Hussain H, Jabbar A, Shafiq N, and Krohn K

Subjects
Anti-Bacterial Agents chemistry, Anti-Bacterial Agents isolation & purification, Biological Products chemistry, Biological Products isolation & purification, Biological Products pharmacology, Dose-Response Relationship, Drug, Lipoxygenase Inhibitors chemistry, Lipoxygenase Inhibitors isolation & purification, Microbial Sensitivity Tests, Molecular Conformation, Polyketides chemistry, Polyketides isolation & purification, Structure-Activity Relationship, Anti-Bacterial Agents pharmacology, Ascomycota chemistry, Bacillus megaterium drug effects, Lipoxygenase metabolism, Lipoxygenase Inhibitors pharmacology, Polyketides pharmacology
Abstract

An antibiotic polyketide, Cryptosporioptide (1) was isolated from the culture extract of the endophytic fungus Cryptosporiopsis sp. The structure of Cryptosporioptide has been established with the help of 1D ((1)H, (13)C), 2D NMR (HSQC, HMBC, COSY, NOESY) techniques and mass spectrometry (FABMS, HRFABMS). The absolute configuration was established by means of electronic circular dichroism (ECD). Cryptosporioptide exhibited both lipoxygenase inhibitory and anti-Bacillus megaterium activities., (Copyright © 2013 Elsevier Ltd. All rights reserved.)

Published
2013
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