1. Transition metal complexes of new glyoxylato-aroylhydrazones and their role in l-ascorbic acid oxidation inhibition
- Author
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Csonka, Róbert, Villalonga-Barber, Carolina, Psycharis, Vassilis, Raptopoulou, Catherine P., and Steele, Barry R.
- Subjects
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TRANSITION metal complexes , *HYDRAZONES , *VITAMIN C , *OXIDATION , *LIGANDS (Chemistry) , *COMPLEX compounds synthesis , *CHELATION , *CRYSTAL structure - Abstract
Abstract: We report here the synthesis of new ligands of the aroylhydrazone family. Glyoxylato-aroylhydrazones (gly-AH) with lipophilic character were designed for possible biological applications where metal chelation is desired. They were found to coordinate readily with a number of metals and the crystal structures of the copper and zinc complexes, M(py)2L (M=Cu, Zn); LH2 (L2)= N′-(2-hydroxy-3-(pentan-3-yl)benzylidene)-2-mesityl-2-oxoacetohydrazide have been determined. The complexes both display a distorted trigonal bipyramidal coordination geometry around the metals. Ascorbate oxidase and ascorbate peroxidase mimicking reactions were carried out to determine the ability of the title ligands to inhibit metal-induced oxidation of l-ascorbic acid via complexes generated in situ. [Copyright &y& Elsevier]
- Published
- 2012
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