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2 results on '"Kong XM"'

1. No association of XRCC1 and CLPTM1L polymorphisms with non-small cell lung cancer in a non-smoking Han Chinese population.

Author

Sun Y, Zhang YJ, and Kong XM

Subjects
Adult, Aged, Aged, 80 and over, Case-Control Studies, China, Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, X-ray Repair Cross Complementing Protein 1, Adenocarcinoma genetics, Asian People genetics, Carcinoma, Non-Small-Cell Lung genetics, Carcinoma, Squamous Cell genetics, DNA-Binding Proteins genetics, Lung Neoplasms genetics, Membrane Proteins genetics, Neoplasm Proteins genetics, Smoking
Abstract

Background: This study aimed to explore potential associations between single nucleotide polymorphisms (SNPs) of the x-ray repair cross-complementing group 1 (XRCC1) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) and non-small cell lung cancer (NSCLC) susceptibility in non-smoker Chinese patients., Methods: A total of 200 NSCLC patients and 200 healthy controls with matched age and gender were recruited for genotyping of XRCC1 SNPs (rs2256507 and rs1001581) and CLPTM1L SNPs (rs401681 and rs4975616). Association of these SNPs with NSCLC risk was evaluated by computing the odds ratio (OR) and 95% confidence interval (CI) from multivariate unconditional logistic regression analyses with adjustment for gender and age., Results: The frequencies of genotype and allele in these four loci (rs2256507, rs1001581, rs401681, and rs4975616) were not significantly different between the cases and controls, or between either of the histological subgroups (adenocarcinoma and squamous cell carcinoma) and controls., Conclusions: Although these SNPs are associated with NSCLC risk in patients with a tobacco-smoking habit, this study demonstrated that XRCC1 and CLPTM1L gene SPNs are not linked with NSCLC risk in non-smoking patients, indicating that molecular mechanisms of NSCLC betwee tobacco smokers and non-smokers may be different. Future studies are needed to uncover the underlying molecular mechanisms for NSCLC in non-smokers.

Published
2013
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2. Lack of associations of polymorphisms of IL-7R, IL-13 and IL-15 with NSCLCs in non-smoking Chinese.

Author

Bao WL, Shi H, Zhang AQ, Kong XM, Deng DH, and Zhang YJ

Subjects
Adenocarcinoma genetics, Adolescent, Adult, Aged, Carcinoma, Squamous Cell genetics, Case-Control Studies, Child, DNA genetics, Female, Follow-Up Studies, Genetic Predisposition to Disease, Humans, Lung Neoplasms genetics, Male, Middle Aged, Prognosis, Real-Time Polymerase Chain Reaction, Risk Factors, Young Adult, Asian People genetics, Carcinoma, Non-Small-Cell Lung genetics, Interleukin-13 genetics, Interleukin-15 genetics, Polymorphism, Single Nucleotide genetics, Receptors, Interleukin-7 genetics, Smoking genetics
Abstract

Studies have shown that immune cells play a key role in lung cancer development. Five SNPs (rs1494555, rs7737000, rs20541, rs1057972 and rs2857261) are associated with lung cancer risk among Caucasians and/or African-Americans, but the polymorphisms may be implicated in different susceptibilities for lung cancer across different populations because of underlying genetic heterogeneity. We therefore conducted a study to examine this relationship in non-smoking Chinese. As a result , no significant associations were observed between SNPs and NSCLCs, whetehr of squamous cell or adenocarcinoma type. Results indicated polymorphisms of IL-7R, IL-13 and IL-15 are not major contributors to NSCLC susceptibility, although we can not rule out synergistic effects with cigarette smoke in NSCLC development in smoking Chinese.

Published
2011

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