1. LRFN2 gene variant rs2494938 provides susceptibility to esophageal cancer in the population of Jammu and Kashmir.
- Author
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Shah, Ruchi, Sharma, Varun, Singh, Hemender, Sharma, Indu, Bhat, Gulzar Ahmed, Shah, Idrees Ayoub, Iqbal, Beenish, Rafiq, Rumisa, Nissa, Najma, Muzaffar, Mansha, Rasool, Malik Tariq, Lone, Ghulam Nabi, Kaul, Sandeep, Lone, Mohd Maqbool, Rai, Ekta, Dar, Nazir Ahmed, and Sharma, Swarkar
- Subjects
ESOPHAGEAL cancer ,GENETIC variation ,GENOME-wide association studies ,CANCER susceptibility ,ASIANS ,ODDS ratio ,TUMOR suppressor genes - Abstract
Background: Leucine‑rich repeat and fibronectin type 2 gene (LRFN2) variant rs2494938 has recently been found associated with esophageal cancer in a genome‑wide association study in an Asian population. However, this association has not been replicated in any Indian population despite high incidence of the disease. Materials and Methods: In the present case–control study, 166 cases and 459 controls were included. Taqman assay technique using real‑time PCR was employed to investigate the association of the variant with esophageal cancer in the population of Jammu and Kashmir (J&K). The Hardy‑Weinberg equilibrium for rs2494938 was assessed using the Chi‑square test. The allele‑ and genotype‑specific risk was estimated by odds ratio (OR) with 95% confidence interval (CI). Results: Variant rs2494938 was observed to be significantly associated with esophageal cancer with an allelic OR of 1.59 (1.23–2.04 at 95% CI, P = 0.0003). Conclusion: The study highlights LRFN2 as a candidate gene for esophageal cancer susceptibility in the population of J&K and calls for a detailed study with a large sample size and involving more ethnic groups of India. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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